Тип публикации: статья из журнала

Год издания: 2022

Идентификатор DOI: 10.3390/brainsci12040495

Ключевые слова: anxiety, ataxia, memantine, rotarod

Аннотация: Memantine is an FDA approved drug for the treatment of Alzheimer’s disease. It reduces neurodegeneration in the hippocampus and cerebral cortex through the inhibition of extrasynaptic NMDA receptors in patients and mouse models. Potentially, it could prevent neurodegeneration in other brain areas and caused by other diseases. We prПоказать полностьюeviously used memantine to prevent functional damage and to retain morphology of cerebellar neurons and Bergmann glia in an optogenetic mouse model of spinocerebellar ataxia type-1 (SCA1). However, before suggesting wider use of memantine in clinics, its side effects must be carefully evaluated. Blockers of NMDA receptors are controversial in terms of their effects on anxiety. Here, we investigated the effects of chronic application of memantine over 9 weeks to CD1 mice and examined rotarod performance and anxiety-related behaviors. Memantine-treated mice exhibited an inability to adapt to anxiety-causing conditions which strongly affected their rotarod performance. A tail suspension test revealed increased signs of behavioral despair. These data provide further insights into the potential deleterious effects of memantine which may result from the lack of adaptation to novel, stressful conditions. This effect of memantine may affect the results of tests used to assess motor performance and should be considered during clinical trials of memantine in patients. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Журнал: Brain Sciences

Выпуск журнала: Vol. 12, Is. 4

Номера страниц: 495

ISSN журнала: 20763425

Издатель: MDPI

• Shuvaev A.N. (Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, 660022, Russian Federation)
• Belozor O.S. (Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, 660022, Russian Federation)
• Mozhei O.I. (Institute of Living Systems, Immanuel Kant Baltic Federal University, Kaliningrad, 236041, Russian Federation)
• Mileiko A.G. (Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, 660041, Russian Federation)
• Mosina L.D. (Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, 660041, Russian Federation)
• Laletina I.V. (Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, 660041, Russian Federation)
• Mikhailov I.G. (Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, 660041, Russian Federation)
• Fritsler Y.V. (Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, 660041, Russian Federation)
• Shuvaev A.N. (Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, 660041, Russian Federation)
• Teschemacher A.G. (Department of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom)
• Kasparov S. (Institute of Living Systems, Immanuel Kant Baltic Federal University, Kaliningrad, 236041, Russian Federation, Department of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom)

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