Aptamer-Targeted Plasmonic Photothermal Therapy of Cancer

Описание

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1016/j.omtn.2017.08.007

Ключевые слова: computer tomography, DNA aptamer, gold nanoparticle, hyperthermia, mouse Ehrlich carcinoma, plasmonic photothermal therapy, positron emission tomography

Аннотация: Novel nanoscale bioconjugates combining unique plasmonic photothermal properties of gold nanoparticles (AuNPs) with targeted delivery using cell-specific DNA aptamers have a tremendous potential for medical diagnostics and therapy of many cell-based diseases. In this study, we demonstrate the high anti-cancer activity of aptamer-coПоказать полностьюnjugated, 37-nm spherical gold nanoparticles toward Ehrlich carcinoma in tumor-bearing mice after photothermal treatment. The synthetic anti-tumor aptamers bring the nanoparticles precisely to the desired cells and selectively eliminate cancer cells after the subsequent laser treatment. To prove tumor eradication, we used positron emission tomography (PET) utilizing radioactive glucose and computer tomography, followed by histological analysis of cancer tissue. Three injections of aptamer-conjugated AuNPs and 5 min of laser irradiations are enough to make the tumor undetectable by PET. Histological analysis proves PET results and shows lower damage of healthy tissue in addition to a higher treatment efficiency and selectivity of the gold nanoparticles functionalized with aptamers in comparison to control experiments using free unconjugated nanoparticles. © 2017 The Authors

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Издание

Журнал: Molecular Therapy - Nucleic Acids

Выпуск журнала: Vol. 9

Номера страниц: 12-21

ISSN журнала: 21622531

Издатель: Cell Press

Авторы

  • Kolovskaya O.S. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation, Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation)
  • Zamay T.N. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Belyanina I.V. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Karlova E. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation, The Federal State-Financed Institution “Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency”, Krasnoyarsk, Russian Federation)
  • Garanzha I. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Aleksandrovsky A.S. (Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Kirichenko A. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation)
  • Dubynina A.V. (Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation)
  • Sokolov A.E. (Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Zamay G.S. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation, Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation)
  • Glazyrin Y.E. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation, Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation)
  • Zamay S. (Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation)
  • Ivanchenko T. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation)
  • Chanchikova N. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation, The Federal State-Financed Institution “Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency”, Krasnoyarsk, Russian Federation)
  • Tokarev N. (The Federal State-Financed Institution “Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency”, Krasnoyarsk, Russian Federation)
  • Shepelevich N. (The Federal State-Financed Institution “Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency”, Krasnoyarsk, Russian Federation)
  • Ozerskaya A. (The Federal State-Financed Institution “Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency”, Krasnoyarsk, Russian Federation)
  • Badrin E. (The Federal State-Financed Institution “Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency”, Krasnoyarsk, Russian Federation)
  • Belugin K. (The Federal State-Financed Institution “Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency”, Krasnoyarsk, Russian Federation)
  • Belkin S. (The Federal State-Financed Institution “Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency”, Krasnoyarsk, Russian Federation)
  • Zabluda V. (Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation)
  • Gargaun A. (University of Ottawa, Department of Chemistry and Biomolecular Sciences, Ottawa, ON, Canada)
  • Berezovski M.V. (University of Ottawa, Department of Chemistry and Biomolecular Sciences, Ottawa, ON, Canada)
  • Kichkailo A.S. (Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetskii, Krasnoyarsk, Russian Federation, Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, Russian Federation)

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