The morphology and phenotype of monocyte-macrophages when cultured on bionanofilms substrates with different surface relief profiles

Описание

Тип публикации: статья из журнала

Год издания: 2020

Идентификатор DOI: 10.3390/biom10010065

Ключевые слова: Alkanoate-based bionanofilms, Atherosclerosis, Monocyte-macrophages morphology, Surface relief

Аннотация: The effect of surface relief profiles of alkanoate-based bionanofilms to the monocyte-macrophages (MN-MPhs) from peripheral blood of patients with atherosclerosis was studied in vitro. Patients were subjected to coronary stenting. Cell morphology and phenotype (expression of CD antigens, levels of production of marker cytokines) inПоказать полностьюvitro were analyzed before and after the installation of stents. It was shown, that the mean square roughness (Rq) of the bionanofilms determined the variability of cell morphology, CD antigens spectraand activity of production interleukins-6 and-10. Also, it was revealed, that the “activity” of the surface topography of biopolymer substrates depends on the functional state of MNs, isolated in different time points: Before and after stenting the ratios of cell morphotypes and production of cytokines in MN-MPhs differed significantly. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

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Издание

Журнал: Biomolecules

Выпуск журнала: Vol. 10, Is. 1

Номера страниц: 65

ISSN журнала: 2218273X

Издатель: MDPI AG

Авторы

  • Menzyanova N.G. (Siberian Federal University, 79, Svobodnyav, Krasnoyarsk, 660041, Russian Federation)
  • Pyatina S.A. (Siberian Federal University, 79, Svobodnyav, Krasnoyarsk, 660041, Russian Federation)
  • Shabanov A.V. (L.V. Kirensky Institute of Physics, Siberian Branch of the Russian Academy of Sciences, 50/38 Akademgorodok, Krasnoyarsk, 660036, Russian Federation)
  • Nemtsev I.V. (Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, 50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation)
  • Stolyarov D.P. (Federal Center for Cardiovascular Surgery, 45 Karaulnaya, Krasnoyarsk, 660020, Russian Federation)
  • Dryganov D.B. (Federal Center for Cardiovascular Surgery, 45 Karaulnaya, Krasnoyarsk, 660020, Russian Federation)
  • Sakhnov E.V. (Federal Center for Cardiovascular Surgery, 45 Karaulnaya, Krasnoyarsk, 660020, Russian Federation)
  • Shishatskaya E.I. (Siberian Federal University, 79, Svobodnyav, Krasnoyarsk, 660041, Russian Federation)

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