Тип публикации: статья из журнала

Год издания: 2024

Идентификатор DOI: 10.3390/diagnostics14050472

Ключевые слова: viral hepatitis C, liver fibrosis, NK cells, subsets, phenotype, receptor expression

Аннотация: <jats:p>Background: NK cells phenotype and functional state in different genotypes of chronic viral hepatitis C (CVHC), depending on liver fibrosis severity, have not been sufficiently studied, which limits the possibilities for the development of pathology therapy. Methods: The CVHC diagnosis was based on the EASL recommendations Показать полностью(2018). Clinical examination with liver elastometry was performed in 297 patients with genotype 1 and in 231 patients with genotype 3 CVHC. The blood NK cells phenotype was determined by flow cytometry in 74 individuals with genotype 1 and in 69 individuals with genotype 3 CVHC. Results: The frequency of METAVIR liver fibrosis stages F3–F4 was 32.5% in individuals with genotype 3, and 20.5% in individuals with genotype 1 CVHC (p = 0.003). In patients with both genotype 1 and genotype 3 CVHC, a decrease in the total number of blood NK cells, CD56brightCD16+ NK cells and an increase in the proportion of CD56dimCD16+ NK cells, CD94+ and CD38 + CD73+ NK cells were registered in patients with fibrosis stage F3–F4 by METAVIR in comparison with persons with METAVIR fibrosis stage F0–F1. Conclusions: In patients with both genotype 1 and genotype 3 CVHC, an imbalance in the ratio between cytokine-producing and cytotoxic NK cells and an increase in the content of NK cells that express inhibitory molecules were determined in patients with severe liver fibrosis.</jats:p>

Журнал: Diagnostics

Выпуск журнала: Т.14, №5

Номера страниц: 472

ISSN журнала: 20754418

Издатель: MDPI AG

• Tsukanov Vladislav Vladimirovich (Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North)
• Savchenko Andrei Anatolyevich (Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North)
• Cherepnin Mikhail Aleksandrovich (Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North)
• Kasparov Eduard Vilyamovich (Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North)
• Tikhonova Elena Petrovna (Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenetsky of the Ministry of Healthcare of Russian Federation)
• Vasyutin Alexander Viktorovich (Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North)
• Tonkikh Julia Leongardovna (Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North)
• Anisimova Anna Alexandrovna (Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenetsky of the Ministry of Healthcare of Russian Federation)
• Belenyuk Vasily Dmitrievich (Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North)
• Borisov Alexandr Gennadyevich (Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North)

• Ядро РИНЦ (eLIBRARY.RU)