Population Cytology of Transgenic Bacteria: Assessment of the Fitness Cost of the Cloned Genes As a Function of DnaA Concentration

Описание

Тип публикации: статья из журнала

Год издания: 2012

Ключевые слова: pollution, crude oil, mammals, rodents, toxicology, pathophysiology

Аннотация: Abstract Our investigation is based on the hypothesis on the dependence of the cell cycle duration on the accumulation of the DnaA - protein that initiates the replication of the chromosome. A fitness cost as the difference between the cell cycle durations of the cells with and without additional cloned genes was determined throughПоказать полностьюthe DnaA accumulation mechanism by the constructed mathematical model. This difference was shown to depend on the level of expression and the number of cloned genes. Also, we investigated two growth conditions of the cell - slow (cell cycle duration < 1h) and fast. During the fast growth the fitness cost was found to be constant, while it increased gradually with decreasing of the growth rate during the slow regime even if the expression of cloned genes does not change

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Издание

Журнал: International Journal of Applied and Fundamental Research

Выпуск журнала: 2

Номера страниц: 17-17

Место издания: Ной-Изенбург

Издатель: ООО Научно-издательский центр Академия Естествознания

Авторы

  • Shuvaev A. (Siberian Federal University)
  • Brilkov A. (Siberian State Aerospace University named after M. F. Reshetnev)

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