Reduction of the cisplatin toxicity by its conjugation with arabinogalactan

Описание

Тип публикации: статья из журнала

Год издания: 2020

Идентификатор DOI: 10.31857/S0233475520010090

Ключевые слова: cisplatin, apoptosis, arabinogalactan, erlich ascites carcinoma, mechanocomposites

Аннотация: Cisplatin is an effective anticancer drug used to treat various types of cancer. The main disadvantage of the drug is its high toxicity. To reduce the toxic effect of cisplatin, we conjugated it with arabinogalactan, which is able to form soluble globules and bind poorly soluble pharmacological compounds by confining them inside spПоказать полностьюheroidal globules. In this study we compared the biological effect and mechanism of action of cisplatin and its complex with arabinogalactan (AG-Pt) on the growth of Ehrlich ascites carcinoma in vivo. The results showed that conjugates of arabinogalactan with platinum exerted a strong antitumor effect despite the fact that the dose of cisplatin in the composition of the conjugates was reduced 10-fold. At the same time, the conjugates of arabinogalactan with platinum were virtually nontoxic. The mechanism of action of cisplatin and its conjugates was almost the same and was associated with the induction of apoptosis of tumor cells. Apparently, a decrease in the toxicity and an increase in the effectiveness of the cisplatin conjugates with arabinogalactan compared with cisplatin is related with a more efficient accumulation of the conjugates in tumor cells that possess asialoglycoprotein receptors mediating the conjugate entry into the cells. © 2020 Russian Academy of Sciences, Institute of Archaeology. All rights reserved.

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Издание

Журнал: Biologicheskie Membrany

Выпуск журнала: Vol. 37, Is. 1

Номера страниц: 69-75

ISSN журнала: 02334755

Авторы

  • Zamay T.N. (Krasnoyarsk Voino-Yasenetsky State University, Krasnoyarsk, 660022, Russian Federation)
  • Starkov A.K. (Institute of Chemistry and Chemical Technologies, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation)
  • Kolovskaya O.S. (Krasnoyarsk Voino-Yasenetsky State University, Krasnoyarsk, 660022, Russian Federation, Federal Research Center "Krasnoyarsk Scientific Center", Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation)
  • Kichkailo A.S. (Krasnoyarsk Voino-Yasenetsky State University, Krasnoyarsk, 660022, Russian Federation, Federal Research Center "Krasnoyarsk Scientific Center", Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation)
  • Inzhevatkin E.V. (Federal Research Center "Krasnoyarsk Scientific Center", Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation)
  • Zamay G.S. (Krasnoyarsk Voino-Yasenetsky State University, Krasnoyarsk, 660022, Russian Federation, Federal Research Center "Krasnoyarsk Scientific Center", Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation)
  • Titova N.M. (Siberian Federal Unoversity, Krasnoyarsk, 660041, Russian Federation)
  • Zamay S.S. (Federal Research Center "Krasnoyarsk Scientific Center", Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russian Federation)
  • Pate Yu.S. (Krasnoyarsk Voino-Yasenetsky State University, Krasnoyarsk, 660022, Russian Federation)

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