Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics

Описание

Тип публикации: статья из журнала

Год издания: 2016

Идентификатор DOI: 10.1016/j.fct.2016.03.003

Ключевые слова: Nanotechnology, Nanoparticles, Nanotoxicology, Nanomedicine, Extracellular matrix, WALLED-CARBON-NANOTUBES, IRON-OXIDE NANOPARTICLES, TITANIUM-DIOXIDE NANOPARTICLES, ALBUMIN-BOUND PACLITAXEL, EPIDERMAL-GROWTH-FACTOR, MESENCHYMAL STEM-CELLS, DRUG-DELIVERY SYSTEMS, PHASE-III TRIAL, IN-VITRO, BREAST-CANCER, Extracellular matrix, Nanomedicine, Nanoparticles, Nanotechnology, Nanotoxicology, biopolymer, carbon nanotube, complement component C1q, copper nanoparticle, gold nanoparticle, interleukin 1beta, interleukin 6, interleukin 8, liposome, monocyte chemotactic protein 1, Extracellular matrix, Nanomedicine, Nanoparticles, Nanotechnology, Nanotoxicology, biopolymer, carbon nanotube, complement component C1q, copper nanoparticle, gold nanoparticle, interleukin 1beta, interleukin 6, interleukin 8, liposome, monocyte chemotactic protein 1

Аннотация: Nanotechnology is an evolving scientific field that has allowed the manufacturing of materials with novel physicochemical and biological properties, offering a wide spectrum of potential applications. Properties of nanoparticles that contribute to their usefulness include their markedly increased surface area in relation to mass, sПоказать полностьюurface reactivity and insolubility, ability to agglomerate or change size in different media and enhanced endurance over conventional-scale substance. Here, we review nanoparticle classification and their emerging applications in several fields; from active food packaging to drug delivery and cancer research. Nanotechnology has exciting therapeutic applications, including novel drug delivery for the treatment of cancer. Additionally, we discuss that exposure to nanostructures incorporated to polymer composites, may result in potential human health risks. Therefore, the knowledge of processes, including absorption, distribution, metabolism and excretion, as well as careful toxicological assessment is critical in order to determine the effects of nanomaterials in humans and other biological systems. Expanding the knowledge of nanoparticle toxicity will facilitate designing of safer nanocomposites and their application in a beneficial manner. (C) 2016 Elsevier Ltd. All rights reserved.

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Издание

Журнал: FOOD AND CHEMICAL TOXICOLOGY

Выпуск журнала: Vol. 91

Номера страниц: 42-57

ISSN журнала: 02786915

Место издания: OXFORD

Издатель: PERGAMON-ELSEVIER SCIENCE LTD

Авторы

  • Piperigkou Zoi (Univ Patras, Dept Chem, Biochem Lab, Biochem Biochem Anal & Matrix Pathobiol Res Grp, Patras, Greece; Fdn Res & Technol Hellas FORTH, Patras, Greece)
  • Karamanou Konstantina (Univ Patras, Dept Chem, Biochem Lab, Biochem Biochem Anal & Matrix Pathobiol Res Grp, Patras, Greece; Univ Fed Rio de Janeiro, Lab Bioquim & Biol Cellular Glicoconjugados, BR-21941 Rio De Janeiro, Brazil)
  • Engin Ayse Basak (Gazi Univ, Fac Pharm, Dept Toxicol, Ankara, Turkey)
  • Gialeli Chrysostomi (Univ Patras, Dept Chem, Biochem Lab, Biochem Biochem Anal & Matrix Pathobiol Res Grp, Patras, Greece; Lund Univ, Malmo Univ Hosp, Dept Lab Med, Malmo, Sweden)
  • Docea Anca Oana (Univ Med & Pharm, Dept Toxicol, Fac Pharm, Craiova, Romania)
  • Vynios Demitrios H. (Univ Patras, Dept Chem, Biochem Lab, Biochem Biochem Anal & Matrix Pathobiol Res Grp, Patras, Greece)
  • Pavao Mauro S. G. (Univ Fed Rio de Janeiro, Lab Bioquim & Biol Cellular Glicoconjugados, BR-21941 Rio De Janeiro, Brazil)
  • Golokhvast Kiri S. (Far Eastern Fed Univ, Sch Engn, Sci Educ Ctr Nanotechnol, Vladivostok, Russia)
  • Shtilman Mikhail I. (DI Mendeleyev Univ Chem Technol, Master Sch Biomat, Moscow, Russia)
  • Argiris Athanassios (Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA)
  • Shishatskaya Ekaterina (Siberian Fed Univ, Dept Med Biol, Krasnoyarsk, Russia)
  • Tsatsakis Aristidis M. (Far Eastern Fed Univ, Sch Engn, Sci Educ Ctr Nanotechnol, Vladivostok, Russia; Univ Crete, Sch Med, Ctr Toxicol Sci & Res, Iraklion, Crete, Greece)

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