Distribution of Ferrihydrite Nanoparticles in the Body and Possibility of Controlling Them in an Isolated Organ by a Permanent Magnetic Field

Описание

Тип публикации: статья из журнала

Год издания: 2020

Идентификатор DOI: 10.1007/s10517-020-04803-y

Ключевые слова: ferrihydrite, intravenous administration, isolated organ, magnetic field, nanoparticles

Аннотация: We studied the distribution of ferrihydrite nanoparticles isolated from bacteria Klebsiella oxytoca in the whole body in vivo and in a cultured isolated organ (liver). The possibility of controlling these nanoparticles in the body using a magnetic field was assessed. One hour after intravenous injection of ferrihydrite nanoparticleПоказать полностьюs to mice, their accumulation was observed in the liver, lungs, and kidneys. Experiment with cultured isolated rat liver showed that these nanoparticles can be controlled by a magnetic field and the influence of magnetic nanoparticles on the liver over 1 h does not lead to destruction of liver cells associated with the release of the marker enzyme AST. These results show the possibility of using magnetic nanoparticles as a system for controlled drug delivery in the body. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

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Издание

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 168, Is. 6

Номера страниц: 789-792

ISSN журнала: 00074888

Издатель: Springer

Авторы

  • Inzhevatkin E.V. (Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation)
  • Osipova E.D. (Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation)
  • Shadrin K.V. (Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation)
  • Pakhomova V.G. (Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation)
  • Rupenko A.P. (Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation)
  • Maksimov N.G. (Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation)
  • Ladygina V.P. (Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation)
  • Yaroslavtsev R.N. (Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Stolyar S.V. (Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation, Siberian Federal University, Krasnoyarsk, Russian Federation)

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