Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1007/s10517-017-3920-x

Ключевые слова: coronary atherosclerosis, fatty acids, inflammation markers, lipid metabolismarachidic acid, 506-30-9, behenic acid, 112-85-6, C reactive protein, 9007-41-4, cholesterol, 57-88-5, interleukin 8, 114308-91-7, myristic acid, 1715-79-3, 544-63-8, palmitic acid, 57-10-3, pentadecanoic acid, 1002-84-2, stearic acid, 57-11-4, 646-29-7

Аннотация: We studied the balance of fatty acids and their correlation with parameters of lipid metabolism and inflammation markers in men with coronary atherosclerosis. In the blood of patients and healthy men, the content of myristic (C14:0), pentadecanoic (C15:0), palmitic (C16:0), stearic (C18:0), arachidic (C20:0) and docosanic (C22:0), Показать полностьюTNFα, IL-1β, IL-6, IL-8, C-reactive protein, cholesterol, triglycerides, HDL, and LPO intensity were measured. In patients with coronary atherosclerosis, increased concentrations of saturated fatty acids, triglycerides, LPO products, IL-6, IL-8, and C-reactive protein were found. Correlation analysis revealed multiple correlations between the studied fatty acids, correlation of C16:0, C18:0, and C20:0 with inflammation markers, C14:0, C16:0, and C18:0 with triglyceride level, C16:0, C18:0, and C20:0 with cholesterol. The contents of C14:0, C15:0, C16:0, and C18:0 correlated with the presence of coronary atherosclerosis. Lipid metabolism disturbances in coronary atherosclerosis were accompanied by changes in not only lipid spectrum and inflammation markers, but also fatty acids balance. © 2017, Springer Science+Business Media, LLC, part of Springer Nature.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 164, Is. 1

Номера страниц: 33-35

ISSN журнала: 00074888

Издатель: Springer New York LLC

• Polonskaya Y.V. (Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russian Federation)
• Shramko V.S. (Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russian Federation)
• Morozov S.V. (N. N. Vorozhtsov Novosibirsk State University of Organic Chemistry, Novosibirsk, Russian Federation)
• Chernyak E.I. (N. N. Vorozhtsov Novosibirsk State University of Organic Chemistry, Novosibirsk, Russian Federation)
• Chernyavsky A.M. (E.N. Meshalkin Siberian Federal Biomedical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russian Federation)
• Ragino Y.I. (Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russian Federation)

• Scopus