Тип публикации: статья из журнала
Год издания: 2014
Идентификатор DOI: 10.1179/1743284713Y.0000000470
Ключевые слова: PHA, Polyhydroxyalkanoates, Biocompatibility, Implantation, Tissue response, Biodegradation, Biodegradable polymers, Copolymers, Degradation, Ion implantation, Microbiology, Tissue, Chemical compositions, Foreign body giant cells, Hydroxybutyric acids, Maximum thickness, Polymer matrices
Аннотация: Matrices based on resorbable polyhydroxyalkanoates (PHAs) of five types {a homopolymer of 3-hydroxybutyric acid, copolymers of 3-hydroxybutyric and 4-hydroxybutyric acids [P(3HB/4HB)], 3-hydroxybutyric and 3-hydroxyvaleric acids [P(3HB/3HV)], 3-hydroxybutyric and 3-hydroxyhexanoic acids [P(3HB/3HHx)]} have been constructed and charПоказать полностьюacterised. No significant differences have been found in tissue response to implantation of these PHAs. Non-coarse fibrous capsules that formed around PHA matrices reached their maximum thickness (60-90 mm) 90 days after implantation; by day 180, the average thickness of the capsules had decreased by 1.5- 2.3 times. The number of foreign body giant cells, resorbing PHAs, remained high. In vivo biodegradation behaviour of polymer matrices is related to the chemical composition of the PHA. Matrices prepared from copolymers P(3HB/4HB) and P(3HB/3HHx) exhibited the fastest degradation rates. P3HB/3HV matrices were degraded more slowly, and P3HB matrices were the most durable. In the PHA matrices that were degraded more slowly, giant cell reaction developed later.
Журнал: MATERIALS SCIENCE AND TECHNOLOGY
Выпуск журнала: Vol. 30, Is. 5
Номера страниц: 549-557
ISSN журнала: 02670836
Место издания: LEEDS
Издатель: MANEY PUBLISHING