In vivo study of 2D PHA matrices of different chemical compositions: tissue reactions and biodegradations

Описание

Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.1179/1743284713Y.0000000470

Ключевые слова: PHA, Polyhydroxyalkanoates, Biocompatibility, Implantation, Tissue response, Biodegradation, Biocompatibility, Biodegradation, Implantation, PHA, Polyhydroxyalkanoates, Tissue response, Biocompatibility, Biodegradable polymers, Copolymers, Degradation, Ion implantation, Microbiology, Tissue, Chemical compositions, Foreign body giant cells, Hydroxybutyric acids, Maximum thickness, PHA, Polyhydroxyalkanoates, Polymer matrices, Tissue response, Biodegradation

Аннотация: Matrices based on resorbable polyhydroxyalkanoates (PHAs) of five types {a homopolymer of 3-hydroxybutyric acid, copolymers of 3-hydroxybutyric and 4-hydroxybutyric acids [P(3HB/4HB)], 3-hydroxybutyric and 3-hydroxyvaleric acids [P(3HB/3HV)], 3-hydroxybutyric and 3-hydroxyhexanoic acids [P(3HB/3HHx)]} have been constructed and charПоказать полностьюacterised. No significant differences have been found in tissue response to implantation of these PHAs. Non-coarse fibrous capsules that formed around PHA matrices reached their maximum thickness (60-90 mm) 90 days after implantation; by day 180, the average thickness of the capsules had decreased by 1.5- 2.3 times. The number of foreign body giant cells, resorbing PHAs, remained high. In vivo biodegradation behaviour of polymer matrices is related to the chemical composition of the PHA. Matrices prepared from copolymers P(3HB/4HB) and P(3HB/3HHx) exhibited the fastest degradation rates. P3HB/3HV matrices were degraded more slowly, and P3HB matrices were the most durable. In the PHA matrices that were degraded more slowly, giant cell reaction developed later.

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Издание

Журнал: MATERIALS SCIENCE AND TECHNOLOGY

Выпуск журнала: Vol. 30, Is. 5

Номера страниц: 549-557

ISSN журнала: 02670836

Место издания: LEEDS

Издатель: MANEY PUBLISHING

Авторы

  • Volova T.G. (Inst Biophys SB RAS, Krasnoyarsk 660036, Russia; Siberian Fed Univ, Inst Modern Biol & Biotechnol, Krasnoyarsk 660041, Russia)
  • Shishatskaya E.I. (Inst Biophys SB RAS, Krasnoyarsk 660036, Russia; Siberian Fed Univ, Inst Modern Biol & Biotechnol, Krasnoyarsk 660041, Russia)
  • Nikolaeva E.D. (Inst Biophys SB RAS, Krasnoyarsk 660036, Russia; Siberian Fed Univ, Inst Modern Biol & Biotechnol, Krasnoyarsk 660041, Russia)
  • Sinskey A.J. (MIT, Dept Biol, Cambridge, MA 02139 USA; MIT, Engn Syst Div, Cambridge, MA 02139 USA; MIT, Hlth Sci Technol Div, Cambridge, MA 02139 USA)

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