Spectroscopic behavior of pyrrolanthrone and its derivative in aprotic and protic solvents

Описание

Тип публикации: доклад, тезисы доклада, статья из сборника материалов конференций

Конференция: 13th International Conference on Atomic and Molecular Pulsed Lasers, AMPL 2017

Год издания: 2018

Идентификатор DOI: 10.1117/12.2303545

Ключевые слова: Absorption, Excited-state dipole moment, Fluorescence, Naphtho[1,2,3-cd]indole-6(2n)-one, Polarity function, Quantum yield, Solute-solvent interaction, Solvatochromism

Аннотация: Recently synthesized pyrrolanthrone, naphtho[1,2,3-cd]indole-6(2H)-one (PyAn), and its water-soluble derivative, 3(naphtho[1,2,3-cd]indole-6(2H)-one-2-yl) sodium propylsulfonate, are very promising for anticancer therapy due to both the fluorescent and cytotoxic properties. The present study is focused on the spectroscopic analysisПоказать полностьюof solvent effects in PyAn and its derivative. An increase of the solvent polarity results in the bathochromic shift in emission and absorption spectra that indicates the involvement of ππ∗-type transition. The double linear correlation of Stokes shift with bulk solvent polarity functions (in terms of Lippert's, Bakhshiev's and Chamma-Viallet's models) and microscopic solvent polarity parameter () 30 N ET for aprotic and protic solvents is observed. Both general and specific solvent effects are revealed for the solute-solvent systems. Fluorescence quantum yield, fluorescence lifetime and excited-state dipole moment were defined for PyAn and its derivative in different solvents for the first time. The obtained information is of a great importance for the characterization of intermolecular interactions of drugs with biomolecules for the development of new drug delivery systems. © 2018 SPIE.

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Издание

Журнал: Proceedings of SPIE - The International Society for Optical Engineering

Выпуск журнала: Vol. 10614

ISSN журнала: 0277786X

Издатель: SPIE

Авторы

  • Merezhko A.G. (Siberian Federal University, 79 Svobodny Prospect, Krasnoyarsk, Russian Federation)
  • Gerasimova M.A. (Siberian Federal University, 79 Svobodny Prospect, Krasnoyarsk, Russian Federation)
  • Gornostaev L.M. (Astafev Krasnoyarsk State Pedagogical University, 89 A. Lebedevoy Str., Krasnoyarsk, Russian Federation)
  • Tropina D.A. (Astafev Krasnoyarsk State Pedagogical University, 89 A. Lebedevoy Str., Krasnoyarsk, Russian Federation)
  • Slyusareva E.A. (Siberian Federal University, 79 Svobodny Prospect, Krasnoyarsk, Russian Federation)

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