Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds

Описание

Тип публикации: статья из журнала

Год издания: 2010

Идентификатор DOI: 10.1007/s11671-010-9571-8

Ключевые слова: Nanodiamonds, Aflatoxin B(1), Detoxification, Adsorbent, Adsorbent, Aflatoxin B 1, Detoxification, Nanodiamonds, Aflatoxin B, Aflatoxin B1, Aflatoxin B <sub>1</sub>, Elevated level, Hematological parameters, Hepatocytes, In-vivo, Lipid inclusions, Liver cells, Nano-diamonds, Oral administration, White blood cells, Adsorption, Aflatoxins, Animals, Blood, Cells, Detoxification, Diamonds, Liver, Scanning electron microscopy, Synthesis (chemical), Rats, Animalia, Rattus

Аннотация: Hematological parameters and the state of liver cells of rats were examined in vivo after the animals received aflatoxin B(1) (AfB(1)) alone and together with modified nanodiamonds (MND) synthesized by detonation. The rats that had received the MND hydrosol had elevated leukocyte levels, mainly due to higher granulocyte counts and Показать полностьюsomewhat increased monocyte counts compared to control rats. Hematological parameters of the rats that had received AfB(1) alone differed from those of the control rats in another way: total white blood cell counts were significantly lower due to the decreased lymphocyte counts. In rats that had consumed AfB(1) with the MND hydrosol, changes in hematological parameters were less pronounced than in rats that had consumed either AfB(1) or MND. Electron microscopy showed that hepatocytes of the rats that had received the MND hydrosol or AfB(1) with the MND hydrosol contained elevated levels of lipid inclusions and lysosomes. Hyperplasia of the smooth endoplasmic reticulum (EPR) was revealed in liver specimens of the rats that had received AfB(1). Results of the study suggest the conclusion about mutual mitigation of the effects of nanoparticles and the mycotoxin on rats blood and liver cells after AfB(1) has adsorbed on MND.

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Издание

Журнал: NANOSCALE RESEARCH LETTERS

Выпуск журнала: Vol. 5, Is. 5

Номера страниц: 908-912

ISSN журнала: 19317573

Место издания: NEW YORK

Издатель: SPRINGER

Авторы

  • Mogilnaya O.A. (Inst Biophys SB RAS, Krasnoyarsk 660036, Russia)
  • Puzyr A.P. (Inst Biophys SB RAS, Krasnoyarsk 660036, Russia)
  • Baron A.V. (Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Krasnoyarsk 660041, Russia)
  • Bondar V.S. (Inst Biophys SB RAS, Krasnoyarsk 660036, Russia)

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