Preparation and crystal structure of hydrated crystalline complex of ciprofloxacin and copper tetrachloride

Описание

Тип публикации: статья из журнала

Год издания: 2005

Идентификатор DOI: 10.1007/s10947-006-0055-8

Ключевые слова: fluoroquinolone; complex formation; copper; ciprofloxacin; hydrogen bonds

Аннотация: Synthesis of a complex formed by ciprofloxacin (cfH) and copper(II) chloride is described; its crystal structure is reported and analyzed in comparison to related compounds. The obtained compound (ctH(3))CuCl4 center dot H2O (cfH(3)(2+) - double protonated cfH molecule) crystallizes as platelets of P2(1)/c symmetry having the unit Показать полностьюcell parameters a = 13.491 (1) angstrom, b = 11.0459(7) angstrom, c = 16.299(1) angstrom; beta = 1.392(7)degrees. Carbonyl oxygen O(1) is protonated, and hydrogen atom combined with it forms an intramolecular hydrogen bond with carboxylic O(2) oxygen (O(1) center dot center dot center dot O(2) = 2.642(5) angstrom). Terminal nitrogen atom N(3) of the piperazinyl group is also protonated, and two its hydrogen atoms participate in hydrogen bonds of N-H center dot center dot center dot Cl type. The structure also has hydrogen bonds O-H center dot center dot center dot O, O-H... Cl with the participation of water molecules which occupy hydrophilic channels. Molecular ions cfH(3)(2+), make couples with intrapair pi center dot center dot center dot pi interactions.

Ссылки на полный текст

Издание

Журнал: JOURNAL OF STRUCTURAL CHEMISTRY

Выпуск журнала: Vol. 46, Is. 2

Номера страниц: 363-370

ISSN журнала: 00224766

Место издания: NEW YORK

Издатель: CONSULTANTS BUREAU/SPRINGER

Персоны

  • Vasil'ev A.D. (Kirenskii Institute of Physics,Siberian Division,Russian Academy of Sciences)
  • Molokeev M.S. (Kirenskii Institute of Physics,Siberian Division,Russian Academy of Sciences)
  • Golovnev N.N. (Krasnoyarsk State University)
  • Churilov T.D. (Krasnoyarsk State University)

Вхождение в базы данных