Elimination of Iron-Containing Magnetic Nanoparticles from the Site of Injection in Mice: a Magnetic-Resonance Imaging Study

Описание

Тип публикации: статья из журнала

Год издания: 2015

Идентификатор DOI: 10.1007/s10517-015-2867-z

Ключевые слова: magnetic nanoparticles, Klebsiella oxytoca, magnetic resonance imaging, elimination

Аннотация: Suspension of magnetic nanoparticles (0.7 g/liter) obtained from Klebsiella oxytoca culture was injected intraperitoneally (1 ml), intramuscularly (in the hip; 100 mu l), and subcutaneously (200 mu l) or administered orally instead of drinking water for 2 days. The presence of magnetic nanoparticles was evaluated detected by MRI inПоказать полностью15 min and 2 h after injections and in 1 and 2 days after the beginning of oral consumption of the suspension. Magnetic nanoparticles were eliminated from the site of intramuscular and intraperitoneal injections and after oral consumption. The period of elimination after intramuscular and intraperitoneal injections did not exceed 2 h, while after oral consumption it corresponded to the time of gastrointestinal tract contents evacuation.

Ссылки на полный текст

Издание

Журнал: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Выпуск журнала: Vol. 158, Is. 6

Номера страниц: 807-811

ISSN журнала: 00074888

Место издания: NEW YORK

Издатель: SPRINGER

Персоны

  • Inzhevatkin E.V. (Russian Acad Sci, Krasnoyarsk Res Ctr, Siberian Div, Krasnoyarsk, Russia; Siberian Fed Univ, Krasnoyarsk, Russia)
  • Morozov E.V. (LV Kirenskii Inst Phys, Krasnoyarsk 660036, Russia; Russian Acad Sci, Nauka Special Designing & Technol Bur, Krasnoyarsk Res Ctr, Siberian Div, Krasnoyarsk, Russia)
  • Khilazheva E.D. (Siberian Fed Univ, Krasnoyarsk, Russia)
  • Ladygina V.P. (Russian Acad Sci, Krasnoyarsk Res Ctr, Siberian Div, Krasnoyarsk, Russia)
  • Stolyar S.V. (LV Kirenskii Inst Phys, Krasnoyarsk 660036, Russia; Siberian Fed Univ, Krasnoyarsk, Russia)
  • Falaleev O.V. (Russian Acad Sci, Krasnoyarsk Res Ctr, Siberian Div, Krasnoyarsk, Russia)

Вхождение в базы данных