Тип публикации: статья из журнала
Год издания: 2018
Идентификатор DOI: 10.1016/j.msec.2017.12.035
Ключевые слова: Biomedicine, Drug delivery, Implants, PHA, Therapeutics, Tissue engineering
Аннотация: As intracellular carbon and energy storage materials, polyhydroxyalkanoates (PHA) are a diverse biopolyesters synthesized by many bacteria. PHA have been produced in large quantity for various application research including medical implants for approximately 30. years. Many studies demonstrated that PHA are promising implant materiПоказать полностьюals due to their diverse and ascendant mechanical, biodegradable and tissue compatible properties. Importantly, common PHA biodegradation products including oligomers and monomers are also not toxic to the cells and tissues. Pharmaceutical applications of some PHA degradation products also have been reported. So far, no study has been reported to have any carcinogenesis result induced by any PHA or their biodegradation products. All results suggest that PHA could be developed into various bio-implant products. © 2018 Elsevier B.V.
Журнал: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Выпуск журнала: Vol. 86
Номера страниц: 144-150
ISSN журнала: 09284931
Место издания: AMSTERDAM
Издатель: ELSEVIER SCIENCE BV