Тип публикации: статья из журнала
Год издания: 2016
Идентификатор DOI: 10.1007/s10517-016-3574-0
Ключевые слова: hypoxia, K+-ATPase, Na+, rat aorta, Reoxygenation, smooth muscle cells
Аннотация: We analyzed the effects of hypoxia and reoxygenation on changes in contractile activity in rat aortic smooth muscles. Both hypoxia and reoxygenation induced relaxation of smooth muscle cells precontracted with high-potassium Krebs solution (30 mM KCl) or α1-adrenoceptor agonist phenylephrine. Vasodilation resulted from enhancement Показать полностьюof potassium permeability of smooth muscle cell membranes caused by activation of voltage-gated potassium channels (triggered by both precontracting agents) or by opening of ATP-sensitive potassium channels (phenylephrine). In isolated smooth muscle cells, both hypoxia and inhibition of Na+, K+-ATPase with ouabain led to depletion of intracellular store of macroergic substances, reduced potassium concentration, and elevated the content of sodium ions.
Журнал: Bulletin of Experimental Biology and Medicine
Выпуск журнала: Т. 162, № 2
Номера страниц: 195-198
ISSN журнала: 00074888
Место издания: Москва
Издатель: Springer New York Consultants Bureau