Тип публикации: статья из журнала
Год издания: 2014
Идентификатор DOI: 10.1007/s10517-014-2570-5
Ключевые слова: multiple myeloma, malonic dialdehyde, antioxidant enzymes, antioxidant, catalase, ceruloplasmin, glutathione, glutathione peroxidase, glutathione transferase, hemoglobin, oxidizing agent, superoxide dismutase, malonaldehyde, adult, aged, article, clinical article, disease association, disease severity, enzyme activity, enzyme blood level, erythrocyte, erythrocyte level, female, human, human cell, human tissue, male, oxidation, blood, case control study, lipid peroxidation, metabolism, middle aged, oxidative stress, Antioxidants, Case-Control Studies, Humans, Malondialdehyde, Oxidants
Аннотация: Disturbances of the erythrocyte antioxidant system presented by LPO intensifi cation were detected in patients with multiple myeloma. Plasma concentrations of MDA in these patients were close to normal due to effective work of the nonenzymatic antioxidant system. Activities of antioxidant enzymes in the plasma were reduced, while cПоказать полностьюatalase activity was high, and ceruloplasmin content did not differ from the control, this indicating suppression of the enzymatic component of the antioxidant system. In erythrocytes, the level of reduced glutathione was low, especially at stage III of the disease. Changes in SOD and catalase activities were similar to those in the plasma, while activities of glutathione-dependent enzymes were comparable to those in normal human erythrocytes.
Журнал: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Выпуск журнала: Vol. 157, Is. 3
Номера страниц: 375-379
ISSN журнала: 00074888
Место издания: NEW YORK
Издатель: SPRINGER