Тип публикации: статья из журнала
Год издания: 2010
Ключевые слова: Alcoholic nephropathy, Alcoholism, Free radical processes, antioxidant, free radical, adult, article, human, kidney disease, kidney function test, lipid peroxidation, male, metabolism, oxidation reduction reaction, pathophysiology, withdrawal syndrome, Antioxidants, Free Radicals, Humans, Kidney Diseases, Kidney Function Tests, Oxidation-Reduction, Substance Withdrawal Syndrome
Аннотация: Aim: to study the activity of free radical processes in patients with alcoholism and renal lesion (A+RL) and the implication of depressed efficiency of the regulatory mechanisms limiting the accumulation of highly toxic products of lipid free radical oxidation (LFRO) in the development of secondary nephropathy. Subjects and methodsПоказать полностью. Fifty-seven patients (mean age 31±2.8 years) with a 5-10 history of alcoholism who had been admitted to hospital for uncomplicated alcohol withdrawal syndrome were examined. Alcoholic renal lesion was detected in 17 (29.8%) patients. A control group comprised 20 healthy individuals. The activity of LFRO and antioxidative defense (AOD) was studied. Results. In patients with alcoholism, the study indicators reflecting the activity of LFRO statistically significantly exceeded those in the group of healthy individuals. These patients were found to have also suppressed mechanisms of first- and second-line AOD in the A+RL group. Conclusion. LFRO activation developing in the presence of suppressed AOD seems to contribute to the development of secondary nephropathy in patients with alcoholism.
Журнал: Terapevticheskii Arkhiv
Выпуск журнала: Vol. 82, Is. 6
Номера страниц: 32-34