Тип публикации: статья из журнала

Год издания: 2015

Идентификатор DOI: 10.1186/1471-2164-16-S13-S4

Ключевые слова: Functionally important substitutions, Homo sapiens denisova, Homo sapiens neanderthalensis, MiRNA, microRNA, animal tissue, Article, brain development, brain function, comparative study, controlled study, gene expression, gene function, gene identification, gene targeting, genome analysis, hominid, Homo neanderthalensis, molecular dynamics, molecular evolution, nonhuman, postnatal development, prenatal development, sequence analysis, species difference

Аннотация: Background: As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo sapiens neanderthalensis and Homo sapiens denisova, and elucidated the expression of their target mRПоказать полностьюNAs in bain. Results: A comparative analysis of the genomes of primates, including species in the genus Homo, identified a group of miRNA genes having fixed substitutions with important implications for the evolution of Homo sapiens neanderthalensis and Homo sapiens denisova. The mRNAs targeted by miRNAs with mutations specific for Homo sapiens denisova exhibited enhanced expression during postnatal brain development in modern humans. By contrast, the expression of mRNAs targeted by miRNAs bearing variations specific for Homo sapiens neanderthalensis was shown to be enhanced in prenatal brain development. Conclusions: Our results highlight the importance of changes in miRNA gene sequences in the course of Homo sapiens denisova and Homo sapiens neanderthalensis evolution. The genetic alterations of miRNAs regulating the spatiotemporal expression of multiple genes in the prenatal and postnatal brain may contribute to the progressive evolution of brain function, which is consistent with the observations of fine technical and typological properties of tools and decorative items reported from archaeological Denisovan sites. The data also suggest that differential spatial-temporal regulation of gene products promoted by the subspecies-specific mutations in the miRNA genes might have occurred in the brains of Homo sapiens denisova and Homo sapiens neanderthalensis, potentially contributing to the cultural differences between these two archaic hominines. © 2015 Gunbin et al.

Журнал: BMC Genomics

Выпуск журнала: Vol. 16, Is. 13

• Gunbin K.V. (Russian Academy of Sciences, Center of Brain Neurobiology and Neurogenetics, Federal State Research Center Institute of Cytology and Genetics, Siberian Branch, Akademika Lavrenti'eva Ave. 10, Novosibirsk, Russian Federation, Novosibirsk Stat)
• Afonnikov D.A. (Russian Academy of Sciences, Center of Brain Neurobiology and Neurogenetics, Federal State Research Center Institute of Cytology and Genetics, Siberian Branch, Akademika Lavrenti'eva Ave. 10, Novosibirsk, Russian Federation)
• Kolchanov N.A. (Russian Academy of Sciences, Center of Brain Neurobiology and Neurogenetics, Federal State Research Center Institute of Cytology and Genetics, Siberian Branch, Akademika Lavrenti'eva Ave. 10, Novosibirsk, Russian Federation, National Rese)
• Derevianko A.P. (Novosibirsk State University, Pirogova St. 2, Novosibirsk, Russian Federation, Russian Academy of Sciences, Siberian Branch, Institute of Archaeology and Ethnography, Akademika Lavrent'eva Ave. 17, Novosibirsk, Russian Federation)
• Rogaev E.I. (Russian Academy of Sciences, Center of Brain Neurobiology and Neurogenetics, Federal State Research Center Institute of Cytology and Genetics, Siberian Branch, Akademika Lavrenti'eva Ave. 10, Novosibirsk, Russian Federation, Lomonosov Moscow)

• Scopus