Тип публикации: статья из журнала
Год издания: 2025
Идентификатор DOI: 10.1007/s11144-025-02852-w
Ключевые слова: microparticles, polyhydroxyalkanoates, drug release, Release Kinetics, Higuchi
Аннотация: In this work, spray-dried poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microparticles (P(3HB-co-3HV) MPs) containing conventional antibacterial drug rifampicin (RIF), as well as novel cytostatic ozonide (OZ) were obtained and characterized. The efect of drug chemical structure on its encapsulation and release profle, as well as MPsПоказать полностьюcharacteristics (mean size, polydispersity index, zeta potential) was investigated. The obtained RIF-MPs and OZ-MPs revealed the mean diameter of 3.14±0.08 μm and 1.94±0.05 μm, respectively, spherical shape, smooth surface and uniform size distribution. The release of RIF and OZ from the P(3HB-co-3HV) microparticulate matrix had a two-stage pattern with the burst efect and followed the Fickian difusion-controlled mechanism.
Журнал: Reaction Kinetics, Mechanisms and Catalysis
ISSN журнала: 18785190