The Model of Fungal Population Dynamics Affected by Nystatin


Тип публикации: статья из журнала

Год издания: 2010

Идентификатор DOI: 10.1002/qua.22050

Ключевые слова: dynamics model, nystatin, osmotic shock, yeast extract, Saccharomyces cerevisiae, Saccharomyces cerevisiae, Antibiotic treatment, Dynamics models, Fungal disease, Liquid medium, Microbial populations, Microbial resistance, Model system, NaCl solution, New mechanisms, Osmotic gradients, Osmotic shocks, Saccharomyces cerevisiae yeast, Side effect, Solid media, Yeast extracts, Cell death, Drug dosage, Drug interactions, Dynamics, Glucose, Liquids, Mathematical models, Osmosis, Sodium chloride, Yeast, Antibiotics

Аннотация: Fungal diseases are acute problems of the up-to-day medicine. Significant increase of resistance of microorganisms to the medically used antibiotics and a lack of new effective drugs follows in a growth of dosage of existing chemicals to solve the problem. Quite often such approach results in side effects on humans. Detailed study Показать полностьюof fungi-antibiotic dynamics can identify new mechanisms and bring new ideas to overcome the microbial resistance with a lower dosage of antibiotics. In this study, the dynamics of the microbial population under antibiotic treatment was investigated. The effects of nystatin on the population of Saccharomyces cerevisiae yeasts were used as a model system. Nystatin effects were investigated both in liquid and solid media by viability tests. Dependence of nystatin action on osmotic gradient was evaluated in NaCl solutions. Influences of glucose and yeast extract were additionatly analyzed. A "stepwise" pattern of the cell death caused by nystatin was the most intriguing. This pattern manifested in periodical changes of the stages of cell death against stages of resistance to the antibiotic. The mathematical model was proposed to describe cell-antibiotic interactions and nystatin viability effects in the liquid medium. The model implies that antibiotic ability to cause a cells death is significantly affected by the intracellular compounds, which came out of cells after their osmotic barriers were damaged. (C) 2009 Wiley Periodicals, Inc. Int J Quantum Chem 110: 242-251, 2010

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Выпуск журнала: Vol. 110, Is. 1

Номера страниц: 242-251

ISSN журнала: 00207608

Место издания: HOBOKEN



  • Voychuk Sergei I. (NAS Ukraine, Inst Microbiol & Virol, Kiev, Ukraine)
  • Gromozova Elena N. (NAS Ukraine, Inst Microbiol & Virol, Kiev, Ukraine)
  • Sadovskiy Mikhail G. (Siberian Fed Univ, RAS, Inst Computat Modelling, SD, Krasnoyarsk, Russia)