Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.1007/s10517-014-2597-7

Ключевые слова: enzymes, macrophages, neutrophils, toxin, Yersinia pseudotuberculosis, adenosine triphosphatase, bacterial toxin, lactate dehydrogenase, peroxidase, animal, apoptosis, chemistry, drug effects, enzyme activation, enzymology, heat, immunology, innate immunity, intraperitoneal drug administration, isolation and purification, macrophage, metabolism, mouse, neutrophil, outbred strain, pathogenicity, primary cell culture, protein stability, Adenosine Triphosphatases, Animals, Animals, Outbred Strains, Bacterial Toxins, Hot Temperature, Immunity, Innate, Injections, Intraperitoneal, L-Lactate Dehydrogenase, Mice

Аннотация: The thermolabile toxin of Yersinia pseudotuberculosis produces a selective dose-dependent stimulating effect on functional activity of innate immunity cells. Prolonged apoptosis-inducing action of the toxin was associated with activation of enzymes of the oxygen-dependent system (LDH and myeloperoxidase) at the early terms of obserПоказать полностьюvation (up to 3 h). In turn, increased number of macrophages with apoptotic changes was noted at the early stages of contact with the thermolabile toxin (5 h), and its further growth was observed against the background of activation of mitochondrial enzymes and production of NO metabolites. © 2014, Springer Science+Business Media New York.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 157, Is. 4

Номера страниц: 483-487

• Plekhova N.G. (Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russian Federation, School of Biomedicine, Far-Eastern Federal University, Vladivostok, Russian Federation)
• Drobot E.I. (Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russian Federation)
• Timchenko N.F. (Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russian Federation)
• Somova L.M. (Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russian Federation)
• Persiyanova E.N. (Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russian Federation)

• Scopus