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Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery

Описание

Тип публикации: статья из журнала

Год издания: 2019

Идентификатор DOI: 10.1080/07373937.2018.1487451

Ключевые слова: Afontova culture, Krasnoyarsk region, Late upper palaeolithic, Sayan mountains, Stone and antler artefacts, Ceftriaxone, P3HB-microparticles, emulsification technique, spray-drying, drug release, microbiological evaluation

Аннотация: The paper deals with the preliminary results of the realization a salvage archaeology project connected with the construction of the railway from Kyzyl to Kuragino (Krasnoyarsk Region, South Siberia) in 2012 and 2015. During the exploration of the multicomponent habitation site of Irba 2 the Pleistocene remains were unearthed beneaПоказать полностьюth the Holocene cultural layers. The finds include bones of bison, reindeer, red deer, giant deer, wild horse, brown bear and hare, lithics, and pieces of worked antler. Radiocarbon dates indicate the Final Pleistocene age (ca. 13 to 11 kyr BP). The assemblage belongs to the Afontova culture, which dominated in the upper reaches of Yenisei during the Final Upper Palaeolithic. Worthy of special note is a unique engraved oval-shaped flat pebble of white marble. It has 37 lateral grooves, cross-shaped engravings in the central parts of both lateral surfaces and traces of unfinished holes made by boring. The nearest analogs are agalmatolithic discs from the sites of Afontova Gora II and III located at Krasnoyarsk. These objects should probably be considered as amulets. © 2018 High Anthropological School University. All rights reserved. In this study, polymer-based microparticles are used to improve the therapeutic properties of ceftriaxone (CEF) and render them safer. Poly-3-hydroxybutyrate (P3HB) and poly-3-hydroxybutyrate/polyethylene glycol (P3HB-PEG)-based microparticles were prepar In this study, polymer-based microparticles are used to improve the therapeutic properties of ceftriaxone (CEF) and render them safer. Poly-3-hydroxybutyrate (P3HB) and poly-3-hydroxybutyrate/polyethylene glycol (P3HB-PEG)-based microparticles were prepar

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Издание

Журнал: Drying Technology

Выпуск журнала: Vol. 37, Is. 9

Номера страниц: 1131-1142

ISSN журнала: 16089057

Издатель: Taylor and Francis Inc.

Персоны

  • Murueva A.V. (Institute of Biophysics SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS”, Krasnoyarsk, Russian Federation)
  • Shershneva A.M. (Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Abanina K.V. (Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Prudnikova S.V. (Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Shishatskaya E.I. (Institute of Biophysics SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS”, Krasnoyarsk, Russian Federation; Institute of Fundamental Biology and Biotechnology, Siberian Federal University, Krasnoyarsk, Russian Federation)

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