Тип публикации: статья из журнала
Год издания: 2024
Идентификатор DOI: 10.3390/ijms25158444
Аннотация: <jats:p>Pseudomonas aeruginosa is an opportunistic pathogen that causes severe infections in compromised hosts. P. aeruginosa infections are difficult to treat because of the inherent ability of the bacteria to develop antibiotic resistance, secrete a variety of virulence factors, and form biofilms. The secreted aminopeptidase (PaAПоказать полностьюP) is an emerging virulence factor, key in providing essential low molecular weight nutrients and a cardinal modulator of biofilm development. PaAP is therefore a new potential target for therapy of P. aeruginosa infections. The present review summarizes the current knowledge of PaAP, with special emphasis on its biochemical and enzymatic properties, activation mechanism, biological roles, regulation, and structure. Recently developed specific inhibitors and their potential as adjuncts in the treatment of P. aeruginosa infections are also described.</jats:p>
Журнал: International Journal of Molecular Sciences
Выпуск журнала: Т. 25, № 15
Номера страниц: 8444
ISSN журнала: 16616596
Место издания: Basel
Издатель: Molecular Diversity Preservation International