Manipulation of Ralstonia eutropha carbon storage pathways to produce useful bio-based products


Тип публикации: статья из журнала

Год издания: 2012

Идентификатор DOI: 10.1007/978-94-007-5055-5_17

Ключевые слова: Biotechnology, Carbon flux, Metabolic engineering, Polyhydro xyalkanoate, Ralstonia eutropha, Cupriavidus necator, Negibacteria, biological product, carbon, polyhydroxyalkanoic acid, biosynthesis, gene expression regulation, genetic engineering, genetics, metabolism, methodology, review, Biological Products, Gene Expression Regulation, Bacterial, Metabolic Networks and Pathways, Polyhydroxyalkanoates

Аннотация: Ralstonia eutropha is a Gram-negative betaproteobacterium found natively in soils that can utilize a wide array of carbon sources for growth, and can store carbon intracellularly in the form of polyhydroxyalkanoate. Many aspects of R. eutropha make it a good candidate for use in biotechnological production of polyhydroxyalkanoate aПоказать полностьюnd other bio-based, value added compounds. Manipulation of the organism’s carbon flux is a cornerstone to success in developing it as a biotechnologically relevant organism. Here, we examine the methods of controlling and adapting the flow of carbon in R. eutropha metabolism and the wide range of compounds that can be synthesized as a result. The presence of many different carbon utilization pathways and the custom genetic toolkit for manipulation of those pathways gives R. eutropha a versatility that allows it to be a biotechnologically important organism. © 2012 Springer Science+Business Media Dordrecht.

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Журнал: Sub-Cellular Biochemistry

Выпуск журнала: Vol. 64

Номера страниц: 343-366


  • Brigham C.J.
  • Zhila N. (Institute of Biophysics, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Shishatskaya E. (Institute of Biophysics, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Volova T.G. (Institute of Biophysics, Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Sinskey A.J.

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