Тип публикации: статья из журнала
Год издания: 2014
Идентификатор DOI: 10.1134/S1990750814020097
Ключевые слова: Bacterial infection, Enzymes, Innate immune cells, Nitric oxide, myeloperoxidase, nitrite, adult, animal cell, animal experiment, animal model, article, bacterial load, bacterial virulence, cell metabolism, cell migration, controlled study, enzyme activity, guinea pig, immune response, immunocompetent cell, innate immunity, Listeria monocytogenes, listeriosis, macrophage, male, mouse, neutrophil, nonhuman, priority journal, rat, Salmonella enteritidis, salmonellosis, Staphylococcus aureus, Staphylococcus infection, Yersinia pseudotuberculosis, Yersinia pseudotuberculosis infection
Аннотация: Metabolic activity of innate immune cells infected by various doses of Gram-negative (Yersinia pseudotuberculosis, Salmonella enteritidis) and Gram positive (Staphylococcus aureus, Listeria monocytogenes) bacteria has been investigated. Using various animal models we found that in during the initial period (up to 2 days) the changeПоказать полностьюs in cellular responses depend on the type of the pathogen. In response to infection caused by Gram-negative bacteria predominant of neutrophil accumulation in the foci of inflammation was observed, while Gram-positive bacteria induced preferential accumulation of macrophages. The study of metabolism of these cells showed that the response of terminally differentiated primed phagocytes to pathogen appearance was higher than in cells circulating in blood. In addition to the priming state the phagocyte reactivity is influenced by the bacterial load. At a low phagocyte/microbe ratio the cells reaction is almost undetectable, while an excess of microorganisms causes (despite of the increase of the phagocytic parameters) the hyperactivation of cell metabolism and production of maximal amounts of bactericide agents, which exhibit a damaging effect on the cell itself. © Pleiades Publishing Ltd. 2014.
Журнал: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Выпуск журнала: Vol. 8, Is. 2
Номера страниц: 155-163