Тип публикации: статья из журнала

Год издания: 2008

Идентификатор DOI: 10.1007/s10517-008-0262-8

Ключевые слова: H5N1 avian influenza virus (A/Gs/Krasnoozerskoye/627/05), Liver, Morphological study, animal cell, animal experiment, animal model, animal tissue, article, avian influenza, controlled study, cytokine production, hemodynamics, hepatitis, Influenza virus A H5N1, liver cell damage, liver failure, liver function, liver necrosis, liver regeneration, liver structure, male, mortality, mouse, nonhuman, proteinosis, structure analysis, Animals, Hepatocytes, Influenza A Virus, H5N1 Subtype, Lymphocytes, Mice, Orthomyxoviridae Infections, Rats, Animalia, Avian influenza virus, Influenza A virus, Mus, Rattus

Аннотация: Intranasal infection of male outbred rats with isolate of influenza A virus subtype H5N1 A/Gs/Krasnoozerskoye/627/05) from the Novosibirsk region was followed by high mortality of experimental animals. Morphological study of liver samples revealed subtotal destructive changes in the liver parenchyma (proteinosis and centrolobular nПоказать полностьюecroses), which was related to hemodynamic disorders and cytokine dysregulation. The decrease in reparative activity of hepatocytes was probably followed by hepatocellular failure and contributed to high mortality rate from this infection (up to 85%). © 2008 Springer Science+Business Media, Inc.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 146, Is. 2

Номера страниц: 243-245

• Sharkova T.V. (Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russian Federation)
• Potapova O.V. (Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russian Federation)
• Shkurupy V.A. (Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russian Federation)
• Shestopalov A.M. (State Research Center of Virology and Biotechnology Vector, Federal Service on Surveillance for Consumer Rights Protection and Human Well-being, Novosibirsk Region, Kol'tsovo, Russian Federation)
• Drozdov I.G. (State Research Center of Virology and Biotechnology Vector, Federal Service on Surveillance for Consumer Rights Protection and Human Well-being, Novosibirsk Region, Kol'tsovo, Russian Federation)
• Shestopalova L.V. (Department of Physiology, Novosibirsk State University, Novosibirsk, Russian Federation)

• Scopus