Тип публикации: статья из журнала

Год издания: 2024

Идентификатор DOI: 10.3390/children11080913

Ключевые слова: intellectual disability, autonomic regulation, hormones, physical development

Аннотация: <jats:p>Introduction: The purpose was to study the indicators of physical development of primary-school-aged children with intellectual disability by observing the type of autonomic nervous regulation and their levels of catecholamines and serotonin. Methods: A total of 168 primary school age children were examined, of which 54 hadПоказать полностьюintellectual disability. The autonomic nervous system was assessed using cardiointervalography; anthropometric parameters were applied in accordance with recommendations. The contents of serotonin and catecholamines in blood plasma and lymphocytes were assessed using enzyme immunoassay and luminescent histochemical methods. Results and conclusions: Delayed physical and mental development in children with intellectual disability were associated with low serotonin levels in this group of children. The optimal option for the physical development of children with intellectual disability is a sympathetic type of autonomic nervous regulation, while negative-type vagotonic nervous regulation was associated with the maximum delay in physical development. The hypersympathetic type of nervous regulation was accompanied by minimal changes in physical development, despite the hormonal imbalance in the ratio of catecholamines and serotonin. The level of the neurotransmitter serotonin is a prognostic marker of the physical development of children of primary school age. The total amount of catecholamines and serotonin in blood plasma has a direct relationship with the amount of these neurotransmitters in blood lymphocytes; the more hormones in plasma, the more of them in lymphocytes. Therefore, the determination of the contents of catecholamines and serotonin in lymphocytes can be used as a model for studying neurotransmitters in humans.</jats:p>

Журнал: Children (Basel)

Выпуск журнала: Т. 11, № 8

ISSN журнала: 22279067

• Smirnova Olga V. (Scientific Research Institute of Medical Problems of the North, Separate Division of Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia)
• Ovcharenko Elizaveta S. (Scientific Research Institute of Medical Problems of the North, Separate Division of Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia)
• Kasparov Edward V. (Scientific Research Institute of Medical Problems of the North, Separate Division of Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia)

• Ядро РИНЦ (eLIBRARY.RU)