Тип публикации: статья из журнала

Год издания: 2024

Идентификатор DOI: 10.2174/0113852728296495240409062733

Аннотация: <jats:sec> <jats:title>Abstract:</jats:title> <jats:p>Synthesis of new hybrid organosilicon compounds based on the amides 1- naphthylacetic acid was described. N-Organyl-2-(1-naphthyl)-N-[(triethoxysilyl)methyl]- acetamides were obtained by the reaction of 1-naphthylacetyl chloride with α-silylamines RNHCH2Si(OEt)3 (R = Me, i-Pr anПоказать полностьюd Ph). Their subsequent interaction with N(CH2CH2OH)3 led to the formation of N-organyl-2-(1-naphthyl)-N-(silatranylmethyl)acetamides. The structure of these hybrid compounds was characterized by 1H, 13C, and 29Si NMR spectroscopy. The structure of N-methyl- and N-isopropyl-2-(1-naphthyl)-N-(silatranylmethy)acetamides was confirmed by X-ray diffraction analysis. Results of computational screening showed that these silatranes are bioavailable and have drug-likeness.</jats:p> </jats:sec>

Журнал: Current Organic Chemistry

Выпуск журнала: Т. 28, № 12

Номера страниц: 959-966

ISSN журнала: 13852728

Издатель: Bentham Science Publishers

• Soldatenko Anastasiya S. (Siberian Division of the Russian Academy of Sciences, A.E. Favorsky Irkutsk Institute of Chemistry, 1 Favorsky Street, Irkutsk 664033, Russia)
• Molokeev Maxim S. (Institute of Engineering Physics and Radio Electronic, Siberian Federal University, Krasnoyarsk 660041, Russia)
• Lazareva Nataliya F. (Siberian Division of the Russian Academy of Sciences, A.E. Favorsky Irkutsk Institute of Chemistry, 1 Favorsky Street, Irkutsk 664033, Russia)

• Ядро РИНЦ (eLIBRARY.RU)