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Determining Stability Constants of Complexes Between Ester Betulin Derivatives and beta-Cyclodextrin by Affinity Capillary Electrophoresis : научное издание

Описание

Тип публикации: статья из журнала

Год издания: 2020

Идентификатор DOI: 10.17516/1998-2836-0203

Ключевые слова: drug delivery, host-guest complexes, capillary electrophoresis, binding constants, inclusion complexes

Аннотация: Inclusion complexes of ester betulin derivatives (pentacyclic lupane triterpenoids) with beta-cyclodextrin (alpha-CD) were studied by affinity capillary electrophoresis. Stability constants were calculated from dependencies of viscosity-corrected effective electrophoretic mobilities on beta-CD concentration (0-10 mM) in background Показать полностьюelectrolytes using nonlinear regression fitting. Logarithms of stability constants at 25 degrees C for 1:1 and 1:2 beta-CD complexes of betulin 3,28-diphthalate, betulin 3,28-disuccinate and betulin 3,28-disulfate (95 % confidence interval) are 4.25 (4.16-4.32) and 7.27 (6.73-7.50), 4.38 (4.26-4.48) and 7.58 (6.90-7.84), 4.04 (4.00-4.08) and 5.91 (4.60-6.20), respectively.

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Издание

Журнал: JOURNAL OF SIBERIAN FEDERAL UNIVERSITY-CHEMISTRY

Выпуск журнала: Vol. 13, Is. 4

Номера страниц: 534-541

ISSN журнала: 19982836

Место издания: KRASNOYARSK

Издатель: SIBERIAN FEDERAL UNIV

Персоны

  • Sursyakova Viktoria V. (FRC Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, Krasnoyarsk, Russia)
  • Levdansky Vladimir A. (FRC Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, Krasnoyarsk, Russia)
  • Rubaylo Anatoly (FRC Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, Krasnoyarsk, Russia; Siberian Fed Univ, Krasnoyarsk, Russia)

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