Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1

Описание

Тип публикации: статья из журнала

Год издания: 2021

Идентификатор DOI: 10.1016/j.nbd.2021.105340

Ключевые слова: bergmann glia, cerebellum, excitatory amino acid transporter type 1, purkinje cell, spinocerebellar ataxia type 1

Аннотация: Bergmann glia (BG) are highly specialized radial astrocytes of the cerebellar cortex, which play a key role in the uptake of synaptic glutamate via the excitatory amino acid transporter EAAT1. Multiple lines of evidence suggest that in cerebellar neurodeg

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Издание

Журнал: Neurobiology of Disease

Выпуск журнала: Vol. 154

Номера страниц: 105340

ISSN журнала: 09699961

Издатель: Academic Press Inc.

Авторы

  • Shuvaev Anton N. (Krasnoyarsk State Med Univ, Res Inst Mol Med & Pathobiochem, Partizan Zheleznyak St 1, Krasnoyarsk 660022, Russia)
  • Belozor Olga S. (Krasnoyarsk State Med Univ, Dept Biol Chem Med Pharmaceut & Toxicol Chem, Partizan Zheleznyak St,1, Krasnoyarsk 660022, Russia)
  • Mozhei Oleg (Immanuel Kant Balt Fed Univ, Inst Living Syst, Univ Skaya St,2, Kaliningrad 236041, Russia)
  • Yakovleva Dariya A. (Siberian Fed Univ, Svobodny Pr,79, Krasnoyarsk 660041, Russia)
  • Potapenko Ilya V. (Krasnoyarsk State Med Univ, Res Inst Mol Med & Pathobiochem, Partizan Zheleznyak St 1, Krasnoyarsk 660022, Russia)
  • Shuvaev Andrey N. (Siberian Fed Univ, Svobodny Pr,79, Krasnoyarsk 660041, Russia)
  • Smolnikova Marina V. (Krasnoyarsk State Med Univ, Res Inst Mol Med & Pathobiochem, Partizan Zheleznyak St 1, Krasnoyarsk 660022, Russia; Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Fed Res Ctr,Sci Res Inst Med Problems North, Partizan Zheleznyak St,3G, Krasnoyarsk 660022, Russia)
  • Salmin Vladimir V. (Krasnoyarsk State Med Univ, Dept Med & Biol Phys, Partizan Zheleznyak St 1, Krasnoyarsk 660022, Russia)
  • Salmina Alla B. (Krasnoyarsk State Med Univ, Res Inst Mol Med & Pathobiochem, Partizan Zheleznyak St 1, Krasnoyarsk 660022, Russia; Krasnoyarsk State Med Univ, Dept Biol Chem Med Pharmaceut & Toxicol Chem, Partizan Zheleznyak St,1, Krasnoyarsk 660022, Russia; Res Ctr Neurol, Div Brain Sci, Lab Expt Brain Cytol, Moscow 125367, Russia)
  • Hirai Hirokazu (Gunma Univ, Grad Sch Med, Dept Neurophysiol & Neural Repair, Maebashi, Gumma, Japan)
  • Teschemacher Anja G. (Univ Bristol, Dept Physiol Pharmacol & Neurosci, Bristol, Avon, England)
  • Kasparov Sergey (Immanuel Kant Balt Fed Univ, Inst Living Syst, Univ Skaya St,2, Kaliningrad 236041, Russia; Univ Bristol, Dept Physiol Pharmacol & Neurosci, Bristol, Avon, England)

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