The morphology and phenotype of monocyte-macrophages when cultured on bionanofilms substrates with different surface relief profiles

Описание

Тип публикации: статья из журнала

Год издания: 2020

Идентификатор DOI: 10.3390/biom10010065

Ключевые слова: Alkanoate-based bionanofilms, Atherosclerosis, Monocyte-macrophages morphology, Surface relief

Аннотация: The effect of surface relief profiles of alkanoate-based bionanofilms to the monocyte-macrophages (MN-MPhs) from peripheral blood of patients with atherosclerosis was studied in vitro. Patients were subjected to coronary stenting. Cell morphology and phenotype (expression of CD antigens, levels of production of marker cytokines) inПоказать полностьюvitro were analyzed before and after the installation of stents. It was shown, that the mean square roughness (Rq) of the bionanofilms determined the variability of cell morphology, CD antigens spectraand activity of production interleukins-6 and-10. Also, it was revealed, that the “activity” of the surface topography of biopolymer substrates depends on the functional state of MNs, isolated in different time points: Before and after stenting the ratios of cell morphotypes and production of cytokines in MN-MPhs differed significantly. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Ссылки на полный текст

Издание

Журнал: Biomolecules

Выпуск журнала: Vol. 10, Is. 1

Номера страниц: 65

ISSN журнала: 2218273X

Издатель: MDPI AG

Авторы

  • Menzyanova Natalia G. (Siberian Fed Univ, 79 Svobodnyav, Krasnoyarsk 660041, Russia)
  • Pyatina Svetlana A. (Siberian Fed Univ, 79 Svobodnyav, Krasnoyarsk 660041, Russia)
  • Shabanov Alexander V. (Russian Acad Sci, Siberian Branch, LV Kirensky Phys Inst, 50-38 Akademgorodok, Krasnoyarsk 660036, Russia)
  • Nemtsev Ivan V. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Fed Res Ctr, 50 Akademgorodok, Krasnoyarsk 660036, Russia)
  • Stolyarov Dmitry P. (Fed Ctr Cardiovasc Surg, 45 Karaulnaya, Krasnoyarsk 660020, Russia)
  • Dryganov Dmitry B. (Fed Ctr Cardiovasc Surg, 45 Karaulnaya, Krasnoyarsk 660020, Russia)
  • Sakhnov Eugene V. (Fed Ctr Cardiovasc Surg, 45 Karaulnaya, Krasnoyarsk 660020, Russia)
  • Shishatskaya Ekaterina I. (Siberian Fed Univ, 79 Svobodnyav, Krasnoyarsk 660041, Russia)