Тип публикации: статья из журнала

Год издания: 2024

Идентификатор DOI: 10.1093/nar/gkad800

Аннотация: <jats:title>Abstract</jats:title> <jats:p>The Novel Metagenome Protein Families Database (NMPFamsDB) is a database of metagenome- and metatranscriptome-derived protein families, whose members have no hits to proteins of reference genomes or Pfam domains. Each protein family is accompanied by multiple sequence alignments, Hidden MarПоказать полностьюkov Models, taxonomic information, ecosystem and geolocation metadata, sequence and structure predictions, as well as 3D structure models predicted with AlphaFold2. In its current version, NMPFamsDB hosts over 100 000 protein families, each with at least 100 members. The reported protein families significantly expand (more than double) the number of known protein sequence clusters from reference genomes and reveal new insights into their habitat distribution, origins, functions and taxonomy. We expect NMPFamsDB to be a valuable resource for microbial proteome-wide analyses and for further discovery and characterization of novel functions. NMPFamsDB is publicly available in http://www.nmpfamsdb.org/ or https://bib.fleming.gr/NMPFamsDB.</jats:p>

Журнал: Nucleic Acids Research

Выпуск журнала: Т. 52, № D1

Номера страниц: 502-512

ISSN журнала: 03051048

Издатель: Oxford University Press

• Baltoumas Fotis A (Institute for Fundamental Biomedical Research, BSRC “Alexander Fleming”, Vari, 16672, Greece)
• Karatzas Evangelos (Institute for Fundamental Biomedical Research, BSRC “Alexander Fleming”, Vari, 16672, Greece)
• Liu Sirui (John Harvard Distinguished Science Fellowship Program, Harvard University, Cambridge, MA 02138, USA)
• Ovchinnikov Sergey (John Harvard Distinguished Science Fellowship Program, Harvard University, Cambridge, MA 02138, USA)
• Sofianatos Yorgos (Institute for Fundamental Biomedical Research, BSRC “Alexander Fleming”, Vari, 16672, Greece)
• Chen I-Min (DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720-8150, USA)
• Kyrpides Nikos C (DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720-8150, USA)
• Pavlopoulos Georgios A (Center for New Biotechnologies and Precision Medicine, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Athens 11527, Greece)

• Ядро РИНЦ (eLIBRARY.RU)