Biomedical investigations of biodegradable PHAs


Тип публикации: доклад, тезисы доклада, статья из сборника материалов конференций

Конференция: European Symposium on Biopolymers; Kusadasi, TURKEY; Kusadasi, TURKEY

Год издания: 2008

Идентификатор DOI: 10.1002/masy.200850909

Ключевые слова: biodegradable polymers, PHA, biomedical investigations, ABS resins, Biopolymers, Biotechnology, Bone, Cell culture, Endothelial cells, Fibers, Functional polymers, Osteoblasts, Polymers, Surgery, Abdominal surgeries, Biocompatible, Biodegradable, Biomedical, Bone defects, Ectopic bones, Hepatocytes, In vitro, Microparticles, Oral surgeries, Osteogenesis, Polyhydroxybutyrate, Polymer devices, Ralstonia, Russian academy of sciences, Two types, Polymer films

Аннотация: This work is a review of the results of biomedical studies of polymer devices (films, fibers, microparticles, 3D implants) made from resorbable PHAs synthesized by the bacterium Wautersia (Ralstonia) eutropha B5786, using the technology developed at the institute of Biophysics of the Siberian Branch of the Russian Academy of SciencПоказать полностьюes. Two types of PHAs - polyhydroxybutyrate (PHB) and a hydroxybutyrate/hydroxyvalerate copolymer (PHB/PHV) - have been proven to be biocompatible in vitro in cultures of fibroblasts, endothelial cells, hepatocytes, and osteoblasts, and in short- and long-duration experiments on animals. Polymer films and membranes have been found to be usable as scaffolds for functioning cells and monofilament suture fibers-for stitching muscular-fascial wounds and in abdominal surgery. Ectopic bone formation assay and experiments with the model of segmental osteotomy showed that 3D PHB and PHB/HA implants can be used for reparative osteogenesis. The paper reports beneficial results of using polymers to repair bone defects in oral surgery.

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Выпуск журнала: Vol. 269

Номера страниц: 65-81

ISSN журнала: 10221360

Место издания: WEINHEIM



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