Тип публикации: статья из журнала

Год издания: 2023

Идентификатор DOI: 10.1134/S0036024423100230

Ключевые слова: inclusion complexes, triterpenoids of the lupane series, capillary electrophoresis, binding constant, formation constant, association constant

Аннотация: Using affinity capillary electrophoresis, the stability constants of inclusion complexes of a number of betulin ester derivatives with randomly methylated β-cyclodextrin in 0.0100 M sodium tetraborate (pH 9.18, ionic strength 0.0200 M) at 25°С were determined for the first time. The decimal logarithms of the stability constants of Показать полностью1 : 1 complexes of betulin 3,28-diphthalate, betulin 3,28-disulfate, and betulin 3,28-disuccinate in a 95% confidence interval were 4.64 ± 0.05, 4.78 ± 0.02, and 4.94 ± 0.02, respectively. The logarithms of the stability constants of 1 : 2 complexes of betulin 3,28-diphthalate and betulin 3,28-disulfate were 7.91 (6.66–8.19) and 8.02 (7.63–8.23), respectively. It was determined that betulin 3,28-disuccinate forms only 1 : 1 complex. The obtained stability constants of 1 : 1 complexes are generally higher than those of the complexes of the same compounds with β-cyclodextrin (β-CD) and lower than those for dimethyl-β-CD, γ-CD, and (2-hydroxypropyl)-γ-CD complexes.

Журнал: Russian Journal of Physical Chemistry A

Выпуск журнала: Т.97, №10

Номера страниц: 2225-2230

ISSN журнала: 00360244

Место издания: Moscow

Издатель: Российская академия наук

• Sursyakova V. V. (Institute of Chemistry and Chemical Technology, Federal Research Center “Krasnoyarsk Scientific Center,” Siberian Branch, Russian Academy of Sciences)
• Levdansky V. A. (Institute of Chemistry and Chemical Technology, Federal Research Center “Krasnoyarsk Scientific Center,” Siberian Branch, Russian Academy of Sciences)
• Rubaylo A. I. (Siberian Federal University)

• Ядро РИНЦ (eLIBRARY.RU)