Тип публикации: статья из журнала
Год издания: 2022
Идентификатор DOI: 10.3389/fpsyt.2022.969674
Аннотация: <jats:sec><jats:title>Background</jats:title><jats:p>Assessing the role of oxytocin (OT) in the regulation of social interaction is a promising area that opens up new opportunities for studying the mechanisms of developing autism spectrum disorders (ASD).</jats:p></jats:sec><jats:sec><jats:title>Aim</jats:title><jats:p>To assess thПоказать полностьюe correlation between the salivary OT level and age-related and psychopathological symptoms of children with intellectual disability (ID) and ASD.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We used the clinical and psychopathological method to assess the signs of ASD based on International Classification of Diseases (ICD-10), the severity of ASD was specified by the selected Russian type version “Childhood Autism Rating Scale” (CARS). Patients of both groups had an IQ score below 70 points.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The median and interquartile range of salivary OT levels in patients with ID and ASD were 23.897 [14.260–59.643] pg/mL, and in the group ID without ASD - Me = 50.896 [33.502–83.774] pg/mL (<jats:italic>p</jats:italic> = 0.001). The severity of ASD on the CARS scale Me = 51.5 [40.75–56.0] score in the group ID with ASD, and in the group ID without ASD—at the level of Me = 32 [27.0–38.0] points (<jats:italic>p</jats:italic> < 0.001). According to the results of correlation-regression analysis in the main group, a direct correlation was established between salivary OT level and a high degree of severity of ASD Rho = 0.435 (<jats:italic>p</jats:italic> = 0.005). There was no correlation between the salivary OT level and intellectual development in the group ID with ASD, Rho = 0.013 (<jats:italic>p</jats:italic> = 0.941) and we have found a relationship between oxytocin and intellectual development in the group ID without ASD, Rho = 0.297 (<jats:italic>p</jats:italic> = 0.005). There was no correlation between salivary OT and age, ASD and age.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The results of this study indicate that patients in the group ID with ASD demonstrated a lower level of salivary OT concentration and a direct relationship between the maximum values of this indicator and the severity of autistic disorders, in contrast to patients in the group ID without ASD.</jats:p></jats:sec>
Журнал: Frontiers in Psychiatry
Выпуск журнала: Т. 13
Номера страниц: 1-13
ISSN журнала: 16640640