Тип публикации: статья из журнала

Год издания: 2022

Идентификатор DOI: 10.1002/chem.202200378

Аннотация: Digital drug design reveals DNA aptamers binding SARS-CoV-2: A hybrid in silico et vitro approach, structure and interaction-based drug design, has been developed to create highly specific DNA aptamers for the receptor-binding domain of the SARS-CoV-2 spike protein. The structure and binding affinity of the aptamers were validated Показать полностьюby small-angle X-ray scattering, flow cytometry, and fluorescence polarization. This approach offers a blueprint for the straightforward design of targeting molecules for new pathogens and emerging variants. More information can be found in the Research Article by Y. Alexeev, M. V. Berezovski, A. S. Kichkailo, et al. (DOI: 10.1002/chem.202104481).

Журнал: Chemistry

Выпуск журнала: Т. 28, № 12

ISSN журнала: 09476539

Издатель: Wiley Interscience

• Mironov Vladimir (Department of Chemistry Kyungpook National University Daegu 702-701 South Korea)
• Shchugoreva Irina A. (Laboratory for Biomolecular and Medical Technologies Krasnoyarsk State Medical University Krasnoyarsk 660022 Russia)
• Artyushenko Polina V. (Laboratory for Biomolecular and Medical Technologies Krasnoyarsk State Medical University Krasnoyarsk 660022 Russia)
• Morozov Dmitry (Nanoscience Center and Department of Chemistry University of Jyväskylä Jyväskylä 40014 Finland)
• Borbone Nicola (Department of Pharmacy University of Naples Federico II Naples 80138 Italy)
• Oliviero Giorgia (Department of Molecular Medicine and Medical Biotechnologies University of Naples Federico II Naples 80131 Italy)
• Zamay Tatiana N. (Laboratory for Biomolecular and Medical Technologies Krasnoyarsk State Medical University Krasnoyarsk 660022 Russia)
• Moryachkov Roman V. (Laboratory of Physics of Magnetic Phenomena Kirensky Institute of Physics 660012 Krasnoyarsk Russia)
• Kolovskaya Olga S. (Laboratory for Biomolecular and Medical Technologies Krasnoyarsk State Medical University Krasnoyarsk 660022 Russia)
• Lukyanenko Kirill A. (School of Fundamental Biology and Biotechnology Siberian Federal University Krasnoyarsk 660041 Russia)
• Song Yanling (Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 P. R. China)
• Merkuleva Iuliia A. (State Research Center of Virology and Biotechnology VECTOR Rospotrebnadzor Koltsovo 630559 Russia)
• Zabluda Vladimir N. (Laboratory of Physics of Magnetic Phenomena Kirensky Institute of Physics 660012 Krasnoyarsk Russia)
• Peters Georgy (NRC Kurchatov Institute Moscow 117 259 Russia)
• Koroleva Lyudmila S. (Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090 Russia)
• Veprintsev Dmitry V. (Laboratory for Digital Controlled Drugs and Theranostics Federal Research Center KSC SB RAS Krasnoyarsk 660036 Russia)
• Glazyrin Yury E. (Laboratory for Biomolecular and Medical Technologies Krasnoyarsk State Medical University Krasnoyarsk 660022 Russia)
• Volosnikova Ekaterina A. (State Research Center of Virology and Biotechnology VECTOR Rospotrebnadzor Koltsovo 630559 Russia)
• Belenkaya Svetlana V. (State Research Center of Virology and Biotechnology VECTOR Rospotrebnadzor Koltsovo 630559 Russia)
• Esina Tatiana I. (State Research Center of Virology and Biotechnology VECTOR Rospotrebnadzor Koltsovo 630559 Russia)
• Isaeva Anastasiya A. (State Research Center of Virology and Biotechnology VECTOR Rospotrebnadzor Koltsovo 630559 Russia)
• Nesmeyanova Valentina S. (State Research Center of Virology and Biotechnology VECTOR Rospotrebnadzor Koltsovo 630559 Russia)
• Shanshin Daniil V. (State Research Center of Virology and Biotechnology VECTOR Rospotrebnadzor Koltsovo 630559 Russia)
• Berlina Anna N. (Laboratory of Immunobiochemistry A.N. Bach Institute of Biochemistry Research Center of Biotechnology of the Russian Academy of Sciences Moscow Moscow 119071 Russia)
• Komova Nadezhda S. (Laboratory of Immunobiochemistry A.N. Bach Institute of Biochemistry Research Center of Biotechnology of the Russian Academy of Sciences Moscow Moscow 119071 Russia)
• Svetlichnyi Valery A. (Laboratory of Advanced Materials and Technology Tomsk State University Tomsk 634050 Russia)
• Silnikov Vladimir N. (Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090 Russia)
• Shcherbakov Dmitriy N. (Altai State University Barnaul 656049 Russia)
• Zamay Galina S. (Laboratory for Biomolecular and Medical Technologies Krasnoyarsk State Medical University Krasnoyarsk 660022 Russia)
• Zamay Sergey S. (Department of Molecular Electronics Federal Research Center KSC SB RAS Krasnoyarsk 660036 Russia)
• Smolyarova Tatyana (School of Fundamental Biology and Biotechnology Siberian Federal University Krasnoyarsk 660041 Russia)
• Tikhonova Elena P. (Department of Infectious Diseases and Epidemiology Krasnoyarsk State Medical University Krasnoyarsk 660022 Russia)
• Chen Kelvin H.-C. (Department of Applied Chemistry National Pingtung University Pingtung 900391 Taiwan)
• Jeng U-Ser (Department of Chemical Engineering National Tsing Hua University Hsinchu 30013 Taiwan)
• Condorelli Gerolama (IRCCS Neuromed-Istituto Neurologico Mediterraneo Pozzilli Via Atinense 18 86077 Pozzilli Italy)
• de Franciscis Vittorio (Institute of Genetic and Biomedical Research (IRGB) Research National Council (CNR) Milan 09042 Italy)
• Groenhof Gerrit (Nanoscience Center and Department of Chemistry University of Jyväskylä Jyväskylä 40014 Finland)
• Yang Chaoyong (Institute of Molecular Medicine Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 P. R. China)
• Moskovsky Alexander A. (Department of Chemistry Lomonosov Moscow State University Moscow 119991 Russia)
• Fedorov Dmitri G. (Research Center for Computational Design of Advanced Functional Materials National Institute of Advanced Industrial Science and Technology Tsukuba 305-8560 Japan)
• Tomilin Felix N. (Laboratory of Physics of Magnetic Phenomena Kirensky Institute of Physics 660012 Krasnoyarsk Russia)
• Tan Weihong (College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. China)
• Alexeev Yuri (Computational Science Division Argonne National Laboratory Lemont IL, 60439 USA)
• Berezovski Maxim V. (Department of Chemistry and Biomolecular Sciences Ottawa Ontario K1N6N5 Canada)
• Kichkailo Anna S. (Laboratory for Biomolecular and Medical Technologies Krasnoyarsk State Medical University Krasnoyarsk 660022 Russia)

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