Тип публикации: статья из журнала
Год издания: 2011
Ключевые слова: Antioxidant enzymes, Multiple sclerosis, Oxidative stress, antioxidant, glatiramer, immunological adjuvant, malonaldehyde, peptide, adult, article, blood, case control study, drug effect, enzymology, erythrocyte, human, immunology, lipid peroxidation, metabolism, time, Adjuvants, Immunologic, Antioxidants, Case-Control Studies, Erythrocytes, Humans, Malondialdehyde, Peptides, Time Factors
Аннотация: Activity of erytrocyte glutationperoxidasc (GP), glutationrcductase (GR), glutationtransfcrasc (GT), glucosc-6-phosphatdehydrogcnasc (G6PDH), catalasc and supcroxiddysmutasc (SOD), and also, the level of malonic dialdehyde (MDA) and total antioxidant activity of blood scrum were studied in patients with different types of multiple Показать полностьюsclerosis. Investigation of peripherical blood was carried out on first day of treatment and after standard therapy of Copaxone. All MS patients had high level of MDA and activity of GP in erythrocytes in comparison with a control group. Other antioxidant enzymes of erythrocytes and total antioxidant activity of blood scrum exhibited weak positive dynamics in patients with a relapsing remittance of multiple sclerosis (RRMS). Decrease of activity of antioxidant system in patients with secondary progression multiple sclerosis (SPMS) was more pronounced and remained unchanged after the treatment. This is consistent with the more severe clinical course of thisc disease.
Журнал: Biomeditsinskaya Khimiya
Выпуск журнала: Vol. 57, Is. 6
Номера страниц: 661-670