Тип публикации: статья из журнала

Год издания: 2023

Идентификатор DOI: 10.3390/diagnostics13182961

Ключевые слова: CD3+CD8+, tuberculosis, Tc1, Tc17, Tc2, chemokine receptors, memory CD8+ T cells

Аннотация: he main role in the control of tuberculosis infection is played by macrophages and Th1 and CD8+ T cells. The study aimed to identify the most diagnostically significant CD8+ T cell subsets in tuberculosis patients. Methods: Peripheral blood samples from patients with clinical, radiological, and bacteriologically confirmed pulmonaryПоказать полностьюtuberculosis (TB, n = 32) and healthy subjects (HC, n = 31) were collected and analyzed using 10-color flow cytometry. Results: The frequency of the EM4 CD3+CD8+ cells was reduced in the peripheral blood of patients with pulmonary tuberculosis, while the relative and absolute number of EM1 CD3+CD8+ cells increased compared to the control group. CD57 expression was reduced in patients with pulmonary tuberculosis on EM1, EM2, and pE1 CD3+CD8+ cells, whereas the EM3 cells had a high level of CD57 expression. The relative and absolute number of Tc2 (CCR6–CXCR3–) cells in peripheral blood in patients with pulmonary tuberculosis was increased, while the frequency of Tc1 (CCR6–CXCR3+) was decreased, compared to healthy donors. Conclusions: Patients with pulmonary tuberculosis have an abnormal CD3+CD8+ cell profile and demonstrate their impaired maturation and functional activity.

Журнал: Diagnostics

Выпуск журнала: Т. 13, № 18

Номера страниц: 2961

ISSN журнала: 20754418

Издатель: MDPI AG

• Kudryavtsev I.V. (Federal State Budgetary Institution "Almazov National Medical Research Centre" of the Ministry of Health of the Russian Federation)
• Zinchenko Yulia (Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation)
• Serebriakova Maria (Institution of Experimental Medicine)
• Akisheva Tatiana (Institution of Experimental Medicine)
• Rubinstein Artem (Institution of Experimental Medicine)
• Savchenko Andrei (Federal Research Center «Krasnoyarsk Science Center» of the Siberian Branch of the Russian Academy of Sciences)
• Borisov Alexandr (Federal Research Center «Krasnoyarsk Science Center» of the Siberian Branch of the Russian Academy of Sciences)
• Belenjuk Vasilij (Federal Research Center «Krasnoyarsk Science Center» of the Siberian Branch of the Russian Academy of Sciences)
• Malkova Anna (Ariel University)
• Yablonskiy Piotr (St. Petersburg Research Institute of Phthisiopulmonology)
• Kudlay Dmitry (NRC Institute of Immunology FMBA of Russia)
• Starshinova A.A. (Federal State Budgetary Institution "Almazov National Medical Research Centre" of the Ministry of Health of the Russian Federation)

• Ядро РИНЦ (eLIBRARY.RU)