Grape seed extract-soluplus dispersion and its antioxidant activity : научное издание

Описание

Тип публикации: статья из журнала

Год издания: 2020

Идентификатор DOI: 10.1080/03639045.2020.1788059

Ключевые слова: grape seed extract, proanthocyanidins, antioxidant, soluplus, freeze-drying, dispersion

Аннотация: Objective The main objective of this work was to formulate a nanodispersion containing grape seed extract and analyzed its release profile, antioxidant potential of the prepared formulations. Methods The grape seed extract (GSE) containing proanthocyanidins (PC's) has been dispersed in polymer matrix soluplus (SOLU) by the freeze-dПоказать полностьюrying method. The morphological analysis was carried out using atomic force microscopy (AFM), scanning electron microscopy (SEM) and Transmission electron microscopy (TEM). Thein-vitrorelease of the nanodispersion formulations was evaluated by simulated intestinal fluid (SIF). The antioxidant activity of GSE and the formulation were evaluated by employing variousin-vitroassays such as 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), 2, 2-diphenyl-1- picrylhydrazyl (DPPH), Ferric reducing antioxidant power (FRAP) and peroxidation inhibiting activity. Results The formulation FIII (1:5) resulted in a stable formulation with a higher loading efficiency of 95.36%, a particle size of 69.90 nm, a polydispersity index of 0.154 and a zeta potential value of -82.10 mV. The antioxidant efficiency of GSE-SOLU evaluated by DPPH was found to be 96.7%. The ABTS and FRAP model exhibited a dose-dependent scavenging activity. Linoleic model of FIII formulation and GSE exhibited a 66.14 and 86.58% inhibition respectively at 200 mu g/l. Conclusions The main reason for excellent scavenging activity of the formulations can be attributed to the presence of monomeric, dimeric, oligomeric procyanidins and the phenolic group. The present work denotes that GSE constitutes a good source of PC's and will be useful in the prevention and treatment of free radical related diseases.

Ссылки на полный текст

Издание

Журнал: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Выпуск журнала: Vol. 46, Is. 8

Номера страниц: 1219-1229

ISSN журнала: 03639045

Место издания: ABINGDON

Издатель: TAYLOR & FRANCIS LTD

Авторы

  • Rajakumari R. (Mahatma Gandhi Univ, Int & Interuniv Ctr Nanosci & Nanotechnol, Kottayam, Kerala, India; Siberian Fed Univ, Inst Biophys, Krasnoyarsk, Russia)
  • Volova Tatiana (Siberian Fed Univ, Inst Biophys, Krasnoyarsk, Russia)
  • Oluwafemi Oluwatobi Samuel (Univ Johannesburg, Dept Chem Sci, Johannesburg, South Africa; Univ Johannesburg, Ctr Nanomat Sci Res, Johannesburg, South Africa)
  • Kumar S.Rajesh (Saveetha Dent Coll & Hosp, Saveetha Inst Med & Tech Sci SIMATS, Dept Pharmacol, Chennai, Tamil Nadu, India)
  • Thomas Sabu (Mahatma Gandhi Univ, Int & Interuniv Ctr Nanosci & Nanotechnol, Kottayam, Kerala, India; Mahatma Gandhi Univ, Sch Chem Sci, Kottayam, Kerala, India)
  • Kalarikkal Nandakumar (Mahatma Gandhi Univ, Int & Interuniv Ctr Nanosci & Nanotechnol, Kottayam, Kerala, India; Mahatma Gandhi Univ, Sch Pure & Appl Phys, Kottayam, Kerala, India)

Вхождение в базы данных