Тип публикации: статья из журнала
Год издания: 2022
Идентификатор DOI: 10.1134/s0022093022030097
Ключевые слова: neurogenic niche, neurogenesis, angiogenesis, Cerebrovascular endothelial cells, Local microenvironment
Аннотация: The blood–brain barrier (BBB) is a constellation of cells within the neurovascular unit of the brain that perform the barrier function, being also involved in the mechanisms of neuroplasticity. The BBB permeability relies on the efficiency of making contacts between cerebrovascular endothelial cells, mechanisms of transcellular perПоказать полностьюmeability, and crosstalk between endothelial and perivascular cells, specifically, pericytes and astrocytes. In addition, the BBB permeability is a derivative of the entire neurovascular unit’s activity and affects the processes of neuroplasticity, specifically, neurogenesis, which in the adult brain occurs in specialized neurogenic niches wherein the maintenance of the pool of stem and progenitor cells, their renewal, proliferation, and differentiation are controlled by the local microenvironment. The formation of this microenvironment is largely determined by the BBB permeability in microvessels that make up a vascular basis of neurogenic niches. Therefore, functional coupling of neurogenesis and neoangiogenesis is an important component of the mechanisms underlying brain plasticity. The processes of neoangiogenesis and neurogenesis are interrelated through the effects of a wide range of regulatory molecules: growth factors, cytokines, neuro- and gliotransmitters, metabolites. Modern technologies make it possible to develop new protocols for controlling the activity of cells that form a proneurogenic and/or proangiogenic microenvironment. The review summarizes current ideas on the mechanisms of neuroplasticity that involve cerebrovascular endothelial cells, as well as on the possibilities of controlling or optogenetic targeting of perivascular astroglia.
Журнал: Journal of Evolutionary Biochemistry and Physiology
Выпуск журнала: Т. 58, № 3
Номера страниц: 728-741
ISSN журнала: 00220930
Место издания: Санкт-Петербург
Издатель: Pleiades Publishing, Ltd. (Плеадес Паблишинг, Лтд)