Тип публикации: статья из журнала

Год издания: 2018

Идентификатор DOI: 10.1166/msr.2018.1067

Ключевые слова: CD38, CD157, social behaviour, development, Ultrasonic vocalization, oxytocin

Аннотация: CD38/ADP-ribosyl cyclase and CD157 (bone marrow stromal cell antigen 1, BST-1) belong to the same gene family and play dual roles as enzymes and as receptors. This current review aims to recapitulate our previous findings obtained from CD38 knockout (Cd38 –/–) and CD157 knockout (Cd157 –/–) mice. We focused on general and specific Показать полностьюfeatures of their phenotypes in relation to the gene deletion. Our studies with knockout mice reveal that CD157 as well as CD38 has a role in oxytocin (OT) release, critically regulates social behavior, and may be involved in the development of neurodevelopmental disorders. Our more recent results suggest an important role of CD38, CD157 and OT for early life behaviors in creating an adult vulnerability to neurodevelopmental deficits. OT or OT analogs have optimistic potentials in pharmacological treatments of behavioral impairments associated with neurodevelopmental disorders such as autism spectrum disorder.

Журнал: Messenger

Выпуск журнала: Т. 6, № 1-2

Номера страниц: 99-104

ISSN журнала: 2167955X

Место издания: Santa Clarita

Издатель: American Scientific Publishers

• Lopatina O.L. (Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Kasai Satoka (Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University)
• Cherepanov S.M. (Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University)
• Furuhara Kazumi (Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University)
• Yoshihara Toru (Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University)
• Shabalova Anna A. (Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University)
• Gerasimenko M.N. (Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University)
• Tsuji Chiharu (Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University)
• Yokoyama Shigeru (Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University)
• Higashida Haruhiro (Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University)
• Salmina A.B. (Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)

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