Nucleic Acid Aptamers Increase the Anticancer Efficiency and Reduce the Toxicity of Cisplatin-Arabinogalactan Conjugates In Vivo : научное издание

Описание

Тип публикации: статья из журнала

Год издания: 2022

Идентификатор DOI: 10.1089/nat.2022.0024

Ключевые слова: cisplatin, aptamer, arabinogalactan, cancer chemotherapy, ascites carcinoma

Аннотация: Cisplatin is an effective drug for treating various cancer types. However, it is highly toxic for both healthy and tumor cells. Therefore, there is a need to reduce its therapeutic dose and increase targeted bioavailability. One of the ways to achieve this could be the coating of cisplatin with polysaccharides and specific carriersПоказать полностьюfor targeted delivery. Nucleic acid aptamers could be used as carriers for the specific delivery of medicine to cancer cells. Cisplatin-arabinogalactan-aptamer (Cis-AG-Ap) conjugate was synthesized based on Cis-dichlorodiammineplatinum, Siberian larch arabinogalactan, and aptamer AS-42 specific to heat-shock proteins (HSP) 71 kDa (Hspa8) and HSP 90-beta (Hsp90ab1). The antitumor effect was estimated using ascites and metastatic Ehrlich tumor models. Cis-AG-Ap toxicity was assessed by blood biochemistry on healthy mice. Here, we demonstrated enhanced anticancer activity of Cis-AG-Ap and its specific accumulation in tumor foci. It was shown that targeted delivery allowed a 15-fold reduction in the therapeutic dose of cisplatin and its toxicity. Cis-AG-Ap sufficiently suppressed the growth of Ehrlich's ascites carcinoma, the mass and extent of tumor metastasis in vivo. Arabinogalactan and the aptamers promoted cisplatin efficiency by enhancing its bioavailability. The described strategy could be very promising for targeted anticancer therapy.

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Издание

Журнал: Nucleic Acid Therapeutics

Выпуск журнала: Т.32, 6

Номера страниц: 497-506

ISSN журнала: 21593337

Персоны

  • Zamay Tatiana N. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Starkov Alexander K. (Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS”)
  • Kolovskaya Olga S. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Zamay Galina S. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Veprintsev Dmitry V. (Laboratory for Digital Controlled Drugs and Theranostics, Federal Research Center “Krasnoyarsk Research Center” of the Siberian Branch of the Russian Academy of Science)
  • Luzan Natalia (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Nikolaeva Elena D. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Lukyanenko Kirill A. (Department of Chemistry, Siberian Federal University)
  • Artyushenko Polina V. (Department of Chemistry, Siberian Federal University)
  • Shchugoreva Irina A. (Department of Chemistry, Siberian Federal University)
  • Glazyrin Yury E. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Koshmanova Anastasia A. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Krat Alexey V. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Tereshina Dariya S. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Zamay Sergey S. (Laboratory for Digital Controlled Drugs and Theranostics, Federal Research Center “Krasnoyarsk Research Center” of the Siberian Branch of the Russian Academy of Science)
  • Pats Yuriy S. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Zukov Ruslan A. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)
  • Tomilin Felix N. (Laboratory for Physics of Magnetic Phenomena, Kirensky Institute of Physics, Federal Research Center Krasnoyarsk Science Center SB RAS)
  • Berezovski Maxim V. (Department of Chemistry and Biomolecular Sciences, University of Ottawa)
  • Kichkailo Anna S. (Laboratory For Biomolecular and Medical Technologies, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenecky)

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