Тип публикации: статья из журнала
Год издания: 2022
Идентификатор DOI: 10.20333/25000136-2022-5-109-110
Ключевые слова: aptamers, Glial tumor, NMR tomography, "smart" nanoscalpel, nanodiscs, magnetomechanical therapy
Аннотация: We studied the effectiveness of magnetomechanical therapy in the treatment of brain glial tumors using magnetic nanodiscs functionalized with DNA aptamers to human brain tumor glial cells. • Materials and methods. The formation of a model of human glioblastoma was carried out by intracranial injection of tumor cells of glioblastomaПоказать полностьюobtained from a patient with glioblastoma. Antitumor therapy was carried out using nanodiscs modified with the Gli233 aptamer. The growth of the glial tumor was monitored using NMR tomography. • Results and discussion. Therapy of a glial tumor during 4 sessions of magnetomechanical therapy using a "smart" nanoscalpel in MF (10Hz, 100Oe) led to a significant reduction in its size, while glial tumors in mice that were treated with nanodiscs modified with nonspecific aptamers continued to increase in size. • Conclusion. Microsurgery using three-layer magnetic nanodisks with a quasi-dipole structure (Au/Ni/Au) modified with the specific for glial cells Gli233 aptamer (“smart” nanoscalpel) is effective for the treatment of human glial tumors in the brain.
Журнал: Сибирское медицинское обозрение
Выпуск журнала: № 5
Номера страниц: 109-110
ISSN журнала: 18199496
Место издания: Красноярск
Издатель: Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого