Тип публикации: статья из журнала
Год издания: 2015
Ключевые слова: Bacterial infection, Enzymes, Innate immune cells, Nitric oxide, animal, bacteremia, guinea pig, immunology, innate immunity, Listeria monocytogenes, macrophage, male, metabolism, mouse, Salmonella enterica serovar Enteritidis, Staphylococcus aureus, Yersinia pseudotuberculosis, Animals, Guinea Pigs, Immunity, Innate, Macrophages, Mice, Salmonella enteritidis
Аннотация: Metabolic activity of innate immunity cells infected by various doses of Gram-negative (Yersinia pseudotuberculosis, Salmonella enteritidis) and Gram-positive (Staphylococcus aureus, Listeria monocytogenes) bacteria has been investigated. Using various animal models we found that during the initial period (up to 2 days) changes of Показать полностьюinfection in cellular responses depend on the type of the pathogen. In response to infection caused by Gram-negative bacteria predominant neutrophil accumulation in the foci of inflammation was observed, while Gram-positive bacteria induced preferential accumulation of macrophages. The study of metabolism of these cells showed that the response of terminally differentiated primed phagocytes to pathogen appearance was higher than in cells circulating in blood. In addition to the priming state the phagocyte reactivity is influenced by the bacterial load. At a low phagocyte/microbe ratio the cells reaction is almost undetectable, while an excess of microorganisms causes (despite of the increase of the phagocytic parameters) the hyperactivation of cell metabolism and production of maximal amounts of bactericide agents, which exhibit a damaging effect on the cell itself.
Журнал: Biomeditsinskaya Khimiya
Выпуск журнала: Vol. 61, Is. 1
Номера страниц: 105-114