Тип публикации: статья из журнала
Год издания: 2010
Идентификатор DOI: 10.1002/mc.20633
Ключевые слова: Cancer, Chromosome aberrations, Polymorphism, TP53, arginine, proline, adult, article, cancer classification, chromatid aberration, chromosome aberration, controlled study, DNA polymorphism, female, gene frequency, genetic association, genotype, heterozygosity, human, major clinical study, male, priority journal, TP53 gene, tumor gene, Aged, Aged, 80 and over, Genes, p53, Humans, Middle Aged, Neoplasms, Polymorphism, Genetic
Аннотация: It is well known that the TP53 gene considerably influences on DNA repair processes. Polymorphisms in the TP53 gene, particularly the well-known Arg72Pro in codon 72 of exon 4 (Ex4+119 G>C; rs1042522), can modify the functionality of the p53 protein and activation of DNA repair. Actually, polymorphic variants Arg and Pro were foundПоказать полностьюto have different properties of regulation of TP53-dependent DNA repair target genes, that can effect various levels of chromosome aberrations in cancer patients with these genotypes. Here, we studied frequency of chromatid breaks (CB), chromosome-type aberrations (CTA) and aberrant cells (AC) in cancer patients (n=102) with various Arg72Pro genotypes. It was shown that the Arg variant of TP53 gene is associated with high frequency of AC and chromatid breaks. That is Arg/Arg carriers have more different chromosome aberrations in comparison to individuals with Arg/Pro and Pro/Pro genotypes (P
Журнал: Molecular Carcinogenesis
Выпуск журнала: Vol. 49, Is. 6
Номера страниц: 521-524