Тип публикации: статья из журнала
Год издания: 2021
Идентификатор DOI: 10.1183/13993003.congress-2021.PA3081
Аннотация: MASP-2 is an enzyme for the activation of the lectin pathway of complement. Increased levels of MASP-2 may be harmful due to an unbalanced proinflammatory response and an additional host injury in serious diseases conditions, such as COVID-SARS (Rambaldi, A. et al. Immunobiology 2020; 225). The role of the MASP-2 according to severity and exacerbation of asthma poorly understood and we aimed to evaluate the MASP-2 plasma level according to asthma severity and exacerbation status in children. Methods: In plasma of the 95 children, aged 7-18 (Slavs, Russia) with asthma MASP-2 level were measured using an ELISA. Control group was represented by 70 matched none-asthmatics. Results: In children with virus-induced asthma exacerbation (n=95) MASP-2 plasma concentration increased in severe asthma (Fig. 1). Plasma MASP-2 levels were increased in asthma exacerbation groups vs control, regardless of exacerbation status: remission (n=34) – 490 ng/ml (p = 0,005), virus-induced exacerbation (n=5) – 604 ng/ml, allergen-induced exacerbation (n=54) – 529 (p = 0,0001). Conclusion: Increased levels of MASP may be associated with asthma severity in children during an exacerbation and may be used as a new marker of severe asthma, especially in an allergen-induced exacerbation.
Журнал: European Respiratory Journal, Supplement
Выпуск журнала: Т. 58, № S65
ISSN журнала: 09041850
Издатель: European Respiratory Society