Тип публикации: статья из журнала

Год издания: 2021

Идентификатор DOI: 10.1016/j.apsusc.2021.149334

Ключевые слова: corticosteroids, delivery system, detonation nanodiamonds, modification, prolonged release

Аннотация: The application of detonation nanodiamonds (DNDs) in delivery systems has been demonstrated many times for a variety of substances, including anti-inflammatory drugs, antibiotics, antineoplastic agents, vitamins etc. The applicability of detonation nanodiamonds as a carrier for delivery of corticosteroids is investigated in this stПоказать полностьюudy. Commercial DNDs were modified to obtain particles with high colloidal stability in aqueous suspensions. Physical adsorption was then used to conjugate the DNDs with methylprednisolone sodium succinate and dexamethasone sodium phosphate. The experimental adsorption isotherms were fit with Langmuir and Freundlich adsorption models. The results of in vitro release study demonstrated an explicit prolonged effect of DNDs, due to which a sustained release of the adsorbed drugs was provided.

Журнал: Applied Surface Science

Выпуск журнала: Т. 551

Номера страниц: 149334

ISSN журнала: 01694332

Издатель: Elsevier Science Publishing Company, Inc.

• Kyu Rhee C. (Korea Atomic Energy Research Institute)
• Burov A.E. (Institute of Biophysics SB RAS,Federal Research Center “Krasnoyarsk Science Center SB RAS”)
• Puzyr A.P. (Institute of Biophysics SB RAS,Federal Research Center “Krasnoyarsk Science Center SB RAS”)
• Bondar V.S. (Institute of Biophysics SB RAS,Federal Research Center “Krasnoyarsk Science Center SB RAS”)

• Ядро РИНЦ (eLIBRARY.RU)