Тип публикации: статья из журнала
Год издания: 2014
Идентификатор DOI: 10.1007/s12013-014-9908-5
Ключевые слова: DnaA; Cell cycle; Fitness cost, Cell cycle, DnaA, Fitness cost, Bacteria (microorganisms), bacterial protein, DNA binding protein, DnaA protein, Bacteria, bacterium, cytology, genetics, metabolism, reproductive fitness, ribosome, Bacteria, Bacterial Proteins, DNA-Binding Proteins, Genetic Fitness, Ribosomes
Аннотация: Fitness cost is the measure of the metabolic burden of unneeded gene expression. It is defined as the lag in bacterial cells growth harboring unneeded genes relative to unburdened cells. Separate cells can concurrently adapt to the burden, demonstrating a decrease in or even a disappearance of the lag. The precise mechanisms of thiПоказать полностьюs adaptation are not clearly understood. One possibility is that an increased amount of free ribosomes "absorb" the unnecessary burden. In this work, the mechanism by which an increased concentration of ribosomes could result in faster growth and mask the unneeded gene expression burden is discussed. The initiation time of chromosome replication by the initiator protein DnaA, for which the accumulation speed depends on the ribosomes amount, is taken into account.
Журнал: CELL BIOCHEMISTRY AND BIOPHYSICS
Выпуск журнала: Vol. 70, Is. 1
Номера страниц: 295-299
ISSN журнала: 10859195
Место издания: TOTOWA
Издатель: HUMANA PRESS INC