Тип публикации: статья из журнала

Год издания: 2007

Идентификатор DOI: 10.1007/s10517-007-0139-2

Ключевые слова: Apoptosis, Cytokines, Eosinophils, Recombinant proteins, eotaxin, recombinant interleukin 3, recombinant interleukin 5, adult, article, controlled study, disease association, disease severity, drug activity, eosinophil, eosinophilia, female, human, human cell, human cell culture, in vitro study, incubation time, male, nonhodgkin lymphoma, Adolescent, Case-Control Studies, Cells, Cultured, Chemokines, CC, Humans, Interleukin-3, Interleukin-5, Lymphoma, Non-Hodgkin, Middle Aged

Аннотация: We studied in vitro effects of recombinant interleukin-5, interleukin-3, and eotaxin on programmed death of eosinophils from healthy donors and patients with non-Hodgkin's lymphomas associated with severe blood eosinophilia. Interleukin-5 and eotaxin produced the most potent antiapoptotic effect on eosinophils from healthy donors. Показать полностьюIn patients with non-Hodgkin's lymphomas, spontaneous apoptosis in eosinophilic leukocytes was low and remained unchanged during incubation with recombinant proteins. © Springer Science+Business Media, Inc. 2007.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 143, Is. 4

Номера страниц: 395-398

• Ryazantseva N.V. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation)
• Novitskii V.V. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation)
• Litvinova L.S. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation)
• Tkachenko S.B. (Department of Clinical Physiology and Functional Diagnostics, Russian Medical Academy of Postgraduate Education, Moscow, Russian Federation)
• Kolobovnikova Yu.V. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation)
• Zhukova O.B. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation)
• Grigor'eva E.S. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation)
• Suvorova E.V. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation)
• Knutareva E.N. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation)
• Radzivil T.T. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation)
• Chasovskikh N.Yu. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation)

• Scopus